Multiple Slits regulate the development of midline glial populations and the corpus callosum

Developmental Biology
Divya K UnniLinda J Richards

Abstract

The Slit molecules are chemorepulsive ligands that regulate axon guidance at the midline of both vertebrates and invertebrates. In mammals, there are three Slit genes, but only Slit2 has been studied in any detail with regard to mammalian brain commissure formation. Here, we sought to understand the relative contributions that Slit proteins make to the formation of the largest brain commissure, the corpus callosum. Slit ligands bind Robo receptors, and previous studies have shown that Robo1(-/-) mice have defects in corpus callosum development. However, whether the Slit genes signal exclusively through Robo1 during callosal formation is unclear. To investigate this, we compared the development of the corpus callosum in both Slit2(-/-) and Robo1(-/-) mice using diffusion magnetic resonance imaging. This analysis demonstrated similarities in the phenotypes of these mice, but crucially also highlighted subtle differences, particularly with regard to the guidance of post-crossing axons. Analysis of single mutations in Slit family members revealed corpus callosum defects (but not complete agenesis) in 100% of Slit2(-/-) mice and 30% of Slit3(-/-) mice, whereas 100% of Slit1(-/-); Slit2(-/-) mice displayed complete agenesis of the co...Continue Reading

References

Sep 1, 1992·The Journal of Comparative Neurology·H S Ozaki, D Wahlsten
Jan 3, 2001·Developmental Biology·E HartfussM Götz
May 2, 2001·The Journal of Comparative Neurology·B G Rash, L J Richards
Dec 26, 2001·The Journal of Comparative Neurology·Valérie MarillatAlain Chédotal
Nov 19, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L J Richards
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenlin YuanDavid M Ornitz
Apr 23, 2003·Journal of Neuroscience Methods·Christina M WeaverMarcelo E Vazquez
Sep 16, 2003·Journal of Neurobiology·Tianzhi ShuLinda J Richards
Dec 9, 2003·Neuron·David S TuchVan J Wedeen
May 27, 2004·Nature Neuroscience·William J RosoffGeoffrey J Goodhill
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S Tuch
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shannon W MendesDaniel J Liebl
May 23, 2006·Nature Neuroscience·Karen Müller SmithFlora M Vaccarino
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas R KeebleHelen M Cooper
Jun 7, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher P HessDaniel B Vigneron
Feb 6, 2007·Current Opinion in Neurobiology·Charlotta LindwallLinda J Richards
Mar 22, 2007·Nature Reviews. Neuroscience·Lynn K PaulElliott H Sherr
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guillermina López-BenditoOscar Marín
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tianbo RenLinda J Richards
Mar 13, 2008·The Journal of Comparative Neurology·Céline PlachezLinda J Richards
May 15, 2008·BMC Developmental Biology·Christine E CampbellRichard M Gronostajski
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guy BarryLinda J Richards
Jan 20, 2009·Science·Shahidul M IslamHideaki Tanaka
Mar 23, 2010·NeuroImage·Randal X MoldrichLinda J Richards
Jul 9, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael PiperLinda J Richards
Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander JaworskiMarc Tessier-Lavigne
Oct 5, 2010·NMR in Biomedicine·Derek K Jones, Mara Cercignani

❮ Previous
Next ❯

Citations

Mar 28, 2013·Neural Plasticity·Mitsuaki NishikimiKazunori Nakajima
Feb 16, 2016·Journal of Neurodevelopmental Disorders·Satu MassinenJuha Kere
Feb 12, 2013·Developmental Biology·Eleni-Maria AmanitiThomas Theil
Jul 30, 2014·Frontiers in Human Neuroscience·Rodrigo SuárezLinda J Richards
Dec 9, 2014·Nature Neuroscience·Céline Delloye-BourgeoisValérie Castellani
Jun 1, 2016·Brain Structure & Function·Fahimeh DarkiJuha Kere
Jun 25, 2016·The Journal of Comparative Neurology·Seung-Wan YooRonald L Schnaar
Feb 28, 2017·Human Brain Mapping·Xiaochen SunGaolang Gong
May 16, 2018·Development·Esther T Stoeckli
Oct 21, 2019·Journal of Neurochemistry·Sergi Roig-PuiggrosAlain Chédotal
Apr 21, 2020·Annals of Laboratory Medicine·Soyoung ParkMi-Ae Jang
Feb 23, 2019·AJNR. American Journal of Neuroradiology·V KnezovićM Vukšić
Jul 17, 2020·Frontiers in Cellular Neuroscience·C DebouxA Baron-Van Evercooren
Sep 30, 2020·Development·Noelia S De León ReyesMarta Nieto
Nov 30, 2018·Frontiers in Behavioral Neuroscience·Su Mi ParkShiyong Huang
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Yuko GondaCarina Hanashima
Dec 31, 2020·Cells·Ray Yueh Ku, Masaaki Torii
Apr 4, 2015·Genes & Development·Mathieu Quesnel-VallièresBenjamin J Blencowe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Related Papers

Journal of Anatomy
William AndrewsJohn G Parnavelas
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Hui WangSohyun Ahn
© 2022 Meta ULC. All rights reserved