Multiple sources of calcium for contraction of the human urinary bladder muscle.

British Journal of Pharmacology
C A MaggiA Meli

Abstract

1. KCl, carbachol, neurokinin A and endothelin produced concentration-dependent contractions of mucosa-free muscle strips from the dome of the human urinary bladder. The maximal response to carbachol or neurokinin A exceeded that to KCl, while the maximal response to endothelin approached that to KCl. 2. Nifedipine (1 microM) abolished the response to KCl, reduced the response to carbachol or neurokinin A but had no effect on the response to endothelin. Bay K 8644 (1 microM) markedly potentiated the response to KCl but had little or no effect on the response produced by the other stimulants. 3. Superfusion of the strips with a nominally calcium (Ca)-free medium containing EDTA (1 mM) for 30 min markedly reduced the response to carbachol, neurokinin A and endothelin, although a small response was still evident at high concentrations. Likewise, after a prolonged (60 min) superfusion of the strips with a high K (80 mM) Ca-free medium plus EDTA (1 mM) these three agonists still produced a small contractile response. 4. The nifedipine (1 microM) resistant response to carbachol, neurokinin A or endothelin was markedly depressed by LaCl3 (1 mM). In contrast, the nifedipine-(1 microM) resistant response to carbachol was not modified by...Continue Reading

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Citations

Feb 13, 2003·Neurourology and Urodynamics·Robert M LevinPaul Chichester
Feb 1, 1997·The Journal of Urology·M S DamaserR M Levin
Aug 5, 1999·British Journal of Pharmacology·J G MastersJ I Gillespie
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Fiona J WarnerElizabeth Burcher
Apr 1, 2000·BJU International·I W MillsJ G Noble
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Nov 14, 2012·The Journal of Pharmacy and Pharmacology·Pedro Marcos Gomes SoaresDavid Neil Criddle
Dec 14, 2004·Life Sciences·Luz CandenasJocelyn N Pennefather
Oct 19, 2006·Toxicology and Applied Pharmacology·Jaydip DasguptaDouglas G Tincello
Mar 1, 1996·The Journal of Urology·X P Zeng, E Burcher
Jul 20, 1999·The Journal of Urology·J G MastersJ I Gillespie
Sep 1, 1997·The Journal of Urology·H J YuM S Damaser
Feb 5, 2013·European Journal of Pharmacology·Paolo SanticioliCarlo Alberto Maggi
Apr 21, 2004·Neurourology and Urodynamics·Roland C D EnglandRuth A Elliott
Feb 26, 2000·BJU International·M S DamaserR M Levin
Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jörg W WegenerFranz Hofmann

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