Multiple sources of non-embryonic multipotent stem cells: processed lipoaspirates and dermis as promising alternatives to bone-marrow-derived cell therapies

Cell and Tissue Research
Claudia Sondermann Freitas, Sergio Ranto Dalmau

Abstract

A body of evidence points to the existence of stem cell stores in adult tissues, in addition to the well-known hematopoietic stem cells from bone marrow. Many reports describe the ability of these multipotent cells (developmentally non-compromised with their organs of origin) to give rise to many different cell types in response to specific stimuli. This apparent plasticity provides new perspectives in tissue engineering and suggests the usefulness of these cells in future protocols of autologous transplantation, gene therapy, and tissue reconstitution in a number of pathological processes. Lipoaspirates and dermis represent accessible sources for obtaining such cells, with minimal discomfort to the donor, and might be promising candidates for cell therapy procedures once their features are experimentally accessed. The intention of the present work has been to gather reports on the phenotypic characteristics, profile, and plastic potential of these stem cells.

References

Apr 1, 1996·The Journal of Experimental Medicine·M A GoodellR C Mulligan
Jul 1, 1997·Bone Marrow Transplantation·P PedrazzoliG Robustelli della Cuna
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·K A JacksonM A Goodell
Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Oct 4, 2000·Nature Neuroscience·R GalliA L Vescovi
Jun 9, 2001·Experimental Biology and Medicine·J J MinguellP Conget
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D C ColterD J Prockop
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Dec 1, 2001·Science·D E WrightI L Weissman
Jan 12, 2002·Plastic and Reconstructive Surgery·Hiroshi MizunoMarc H Hedrick
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shannon L McKinney-FreemanMargaret A Goodell
Mar 9, 2002·Plastic and Reconstructive Surgery·Jerry I HuangProsper Benhaim
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Edwin M HorwitzTed Hofmann
Aug 7, 2002·The American Journal of Pathology·Xin WangMarkus Grompe
Sep 24, 2002·Journal of Cell Science·Majlinda LakoColin A B Jahoda
Oct 24, 2002·Blood·Peter J QuesenberryJean-Francois Lambert
Nov 9, 2002·Experimental Hematology·Atsushi Asakura, Michael A Rudnicki
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Feb 6, 2003·Cytotherapy·J K Fraser
Mar 21, 2003·The Annals of Thoracic Surgery·Sunil RangappaEugene Kwang Sim Wei
Apr 1, 2003·Nature·George VassilopoulosDavid W Russell
Apr 25, 2003·Plastic and Reconstructive Surgery·Peter H AshjianMarc H Hedrick
Jun 5, 2003·The Journal of Experimental Medicine·Jean-Francois LambertPeter J Quesenberry
Jun 12, 2003·Annals of the New York Academy of Sciences·Jonathan C HowellEdward F Srour
Jun 12, 2003·Annals of the New York Academy of Sciences·P QuesenberryV Falanga
Jun 12, 2003·Annals of the New York Academy of Sciences·C M VerfaillieY Jiang
Jun 12, 2003·Annals of the New York Academy of Sciences·Willem E Fibbe, Willy A Noort

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Citations

Aug 1, 2009·Cancer Gene Therapy·A P KyritsisJ S Rao
Dec 15, 2007·Nature Reviews. Drug Discovery·Irina KlimanskayaRobert Lanza
Sep 13, 2007·Stem Cell Reviews·Andrew C BoquestPhilippe Collas
Jun 8, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Feras Al BattahSarah Snykers
May 18, 2010·Journal of the American Academy of Dermatology·Klaus Sellheyer, Dieter Krahl
Jun 1, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Elizabeth Cho, Wan-Ju Li
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Susan S TsengA Hari Reddi

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