PMID: 6160849Apr 1, 1980Paper

Multiple structural genes for mouse amylase

Biochemical Genetics
J P HjorthJ T Nielsen

Abstract

Salivary and pancreatic amylases from the mouse show both structural and quantitative genetic variation encoded within a gene complex on chromosome 3. Two fundamental questions prompted by this variation are whether salivary and pancreatic amylases are derived from different structural genes and whether multiple structural genes are causing the quantitative variation observed in each of the two amylases. These questions were approached by comparing the amylase protein from 12 congenic lines carrying amylase gene complexes derived from different origins. The amylases were purified by affinity chromatography employing the inhibitor cyclohepta-amylose and characterized in terms of amino acid composition, specific activity, molecular weight, and heat stability. They were analyzed by native electrophoresis in polyacrylamide gels and by peptide mapping employing both cyanogen bromide cleavage and restricted proteolysis in the presence of dodecylsulfate. By these techniques, many differences in the structure of pancreatic amylase that were not reflected in the salivary amylase were found among mouse strains. Likewise, a distinct salivary amylase variant was found. These results suggest that independent structural genes exist for the t...Continue Reading

References

Aug 1, 1979·Biochemical Genetics·J P Hjorth
May 1, 1976·Canadian Journal of Biochemistry·M P Silvanovich, R D Hill
Jan 1, 1978·Advances in Comparative Physiology and Biochemistry·R C Karn
Jun 1, 1976·Analytical Biochemistry·M P Silvanovich, R D Hill
Nov 1, 1976·The Journal of Heredity·B A Taylor
Dec 28, 1964·Annals of the New York Academy of Sciences·J T CLARKE

❮ Previous
Next ❯

Citations

Jan 1, 1982·Human Genetics·J C PronkG J Tonino
Aug 1, 1981·Biochemical Genetics·W D Dawson, L L Huang
Apr 1, 1984·Biochemical Genetics·K K ThomsenJ T Nielsen
Jun 1, 1982·Biochemical Genetics·R C KarnJ T Nielsen
Aug 1, 1979·Biochemical Genetics·J P Hjorth
Aug 1, 1985·Biochemical Genetics·B M MikkelsenJ P Hjorth
Aug 1, 1987·Biochemical Genetics·P R Paul, R W Elliott
Jan 11, 1985·Nucleic Acids Research·H O Madsen, J P Hjorth
Apr 10, 1987·Nucleic Acids Research·W WarrenC S Cooper
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C DennyR S Redman
Apr 5, 1985·Journal of Molecular Biology·A C Pittet, U Schibler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.