Abstract
Aim of this study is an updated review of our case series (72 patients) as well as available literature on the Multiple Symmetric Lipomatosis (MSL), a rare disease primarily involving adipose tissue, characterized by the presence of not encapsulated fat masses, symmetrically disposed at characteristic body sites (neck, trunk, proximal parts of upper and lower limbs). The disease is more frequent in males, associated to an elevated chronic alcohol consumption, mainly in form of red wine. Familiarity has been reported and MSL is considered an autosomic dominant inherited disease. MSL is associated to severe clinical complications, represented by occupation of the mediastinum by lipomatous tissue with a mediastinal syndrome and by the presence of a somatic and autonomic neuropathies. Hyper-alphalipoproteinemia with an increased adipose tissue lipoprotein-lipase activity, a defect of adrenergic stimulated lipolysis and a reduction of mitochondrial enzymes have been described. The localization of lipomatous masses suggests that MSL lipomas could originate from brown adipose tissue (BAT). Moreover, studies on cultured pre-adipocytes demonstrate that these cells synthetize the mitochondrial inner membrane protein UCP-1, the selective ...Continue Reading
Citations
Nov 27, 2009·Annals of Clinical Biochemistry·Samarina MusaadJohn R Burnett
Feb 13, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Philipp Al GhazalMichael P Schön
Mar 15, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Philipp Al GhazalMichael P Schön
Apr 18, 2017·ELife·Nuno RochaRobert K Semple
Nov 22, 2018·Annals of Plastic Surgery·Shao-Chen WanWen-Chieh Liao
Mar 1, 2019·Clinical Obesity·Michiel P B MoonenWouter D van Marken Lichtenbelt
Mar 29, 2016·Plastic and Reconstructive Surgery·Lukas PrantlOliver Felthaus
May 12, 2017·Wiener medizinische Wochenschrift·Uwe Wollina
May 27, 2020·Journal of Cardiothoracic Surgery·Weijiang MaXin Liu
Sep 14, 2017·Molecular Medicine Reports·Ke ChenZhaohui Mo
Jan 18, 2019·Medicine·Hui GaoXiao-Yu Wen
Sep 16, 2020·BMC Women's Health·Kyunghun Jung, Soonchul Lee
Aug 10, 2017·Aesthetic Plastic Surgery·Yuan GaoYun Lu
Jun 8, 2018·Plastic and Reconstructive Surgery. Global Open·Daniel SchiltzLukas Prantl
May 16, 2018·Clinical Hemorheology and Microcirculation·Oliver FelthausLukas Prantl
Oct 5, 2018·Journal of Investigative Medicine High Impact Case Reports·Uththara PereraRobert A Hegele
Jan 9, 2020·Clinical Genetics·Ester López-GallardoEduardo Ruiz-Pesini
Jan 6, 2021·Cells·Federica CaponnettoPier Camillo Parodi
Dec 4, 2020·World Journal of Clinical Cases·Bo LiXian-Peng Dai
Oct 30, 2020·International Journal of Molecular Sciences·Marta SannaGabriella Milan
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ke ChenZhaohui Mo
Mar 14, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Julliane Tamara Araújo de Melo CamposJosivan Gomes Lima
Mar 23, 2021·World Journal of Clinical Cases·Ke-Ke ChenWei-Hui Yu
Mar 30, 2021·Radiology Case Reports·Cecilia GozzoAntonio Basile
Sep 22, 2018·JAAD Case Reports·Robert Christopher Gilson, Sandra Osswald
Jul 2, 2021·Clinical Case Reports·Christos TsilivigkosTheodoros Papadas