Multiple system atrophy presenting as central sleep apnoea

The European Respiratory Journal
L J CormicanA J Williams

Abstract

A 61-yr-old male presented with apparent idiopathic central sleep apnoea but after 4 yrs developed features of autonomic, cerebellar and extrapyramidal dysfunction consistent with a diagnosis of multiple system atrophy (MSA). Though central sleep apnoea can occur in multiple sleep apnoea, it is less frequent than obstructive sleep apnoea and occurs in the later stages of the disease. The pathogenesis of MSA involves gliosis and neuronal cell loss in specific areas of the central nervous system. Central sleep apnoea in MSA may be due to the depletion of cholinergic neurons in the arcuate nucleus of the medulla by apoptosis. This is the first description of multiple system atrophy presenting as central sleep apnoea. The current authors believe that multiple system atrophy should be considered in the differential diagnosis of late onset central sleep apnoea and progressive hypoventilation.

Citations

Aug 25, 2007·Current Treatment Options in Neurology·Alex Iranzo
Oct 23, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daniela GrimaldiPasquale Montagna
Jan 18, 2012·Current Neurology and Neuroscience Reports·Carles Gaig, Alex Iranzo
Aug 14, 2012·Current Treatment Options in Neurology·Luigi Ferini-Strambi, Sara Marelli
Sep 12, 2008·The Neurologist·Martín A Nogués, Eduardo Benarroch
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Nicholas S HopkinsonMichael I Polkey
Apr 19, 2008·American Journal of Respiratory and Critical Care Medicine·Leanne C McKay, Jack L Feldman
Sep 24, 2010·Case Reports in Medicine·Ramon Andrade Bezerra de MelloJoão Manuel Quinaz
Feb 3, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Roberto VetrugnoPasquale Montagna
Jan 21, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Olivier FlabeauPierre-Olivier Fernagut
Jun 24, 2014·Movement Disorders Clinical Practice·Sabra M Abbott, Aleksandar Videnovic
Dec 24, 2010·Therapeutic Advances in Neurological Disorders·Olivier FlabeauFrançois Tison
Nov 30, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Eduardo E Benarroch
Apr 25, 2019·Expert Review of Respiratory Medicine·Sébastien BaillieulJean-Louis Pépin
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pierantonio LavenezianaDenis E O'Donnell
May 22, 2010·Clinics in Chest Medicine·Lee K Brown

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis