Abstract
Artemisinin-based combination therapies (ACT) are widely used in African countries, including Cameroon. Between 2005 and 2007, five randomized studies comparing different treatment arms among artesunate-amodiaquine and other ACT were conducted in Cameroonian children aged two to 60 months who had uncomplicated Plasmodium falciparum malaria. In these studies, the categorical criterion proposed by the World Health Organization (WHO) to assess the relative effectiveness of anti-malarial drugs was repeatedly evaluated on Days 14, 21 and 28 after treatment initiation. The aim of the present study was to compare the effects of different treatments on this repeated ordinal outcome, hence using the fully available information. The quantitative synthesis was based on individual patient data. Due to the incomplete block design concerning treatment arms between different trials, a mixed treatment comparison (MTC) meta-analysis approach was adopted. The repeated ordinal outcome was modelled through a latent variable, as a proportional odds mixed model with trial, period and treatment arms as covariates. The model was further complexified to account for the variance heterogeneity, and the individual log-residual variance was modelled as a l...Continue Reading
References
Feb 10, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·V Hasselblad
Sep 16, 2003·Statistics in Medicine·A E Ades
Sep 28, 2004·Statistics in Medicine·G Lu, A E Ades
Jul 15, 2005·Health Technology Assessment : HTA·A M GlennyUNKNOWN International Stroke Trial Collaborative Group
Sep 24, 2005·Malaria Journal·Robert HutagalungFrançois H Nosten
Oct 15, 2005·BMJ : British Medical Journal·Deborah M CaldwellJ P T Higgins
Apr 22, 2006·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Susan GriffinStephen Palmer
May 11, 2006·Current Medical Research and Opinion·Jeroen P Jansen
May 18, 2006·Malaria Journal·Martin MeremikwuEmmanuel Ezedinachi
Jun 27, 2006·Lancet·Frank SmithuisNicholas J White
Feb 8, 2007·Statistics in Medicine·G LuD M Caldwell
Mar 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A R HasugianR N Price
Apr 9, 2008·Journal of Clinical Epidemiology·F SongR Lilford
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jeroen P JansenWiro Stam
Jun 12, 2008·PloS One·Adoke YekaHasifa Bukirwa
Nov 20, 2008·Malaria Journal·Petra F MensPiet A Kager
Jan 9, 2009·Malaria Journal·Kassoum KayentaoOgobara K Doumbo
Jun 13, 2009·Computer Methods and Programs in Biomedicine·Jean-Louis Foulley, Florence Jaffrézic
Jul 10, 2009·The Cochrane Database of Systematic Reviews·David SinclairPaul Garner
Aug 25, 2009·Malaria Journal·Julien ZwangMilijaona Randrianarivelojosia
Nov 3, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emmanuel ArinaitweGrant Dorsey
Jan 13, 2010·The American Journal of Tropical Medicine and Hygiene·Babacar FayeOumar Gaye
Feb 23, 2010·Malaria Journal·Solange Youdom WhegangLeonardo K Basco
Mar 9, 2010·Nature Reviews. Microbiology·Arjen M DondorpLorenz von Seidlein
Jun 23, 2010·BMC Medical Research Methodology·Solange Youdom WhegangJean-Christophe Thalabard
Jul 6, 2011·Statistics in Medicine·Helen A DakinSteven Kelly
Citations
Mar 8, 2014·Medicina clínica·Angel Domínguez-Castellano
Feb 18, 2016·Journal of Biopharmaceutical Statistics·Ping YangWai-Yin Poon
Aug 21, 2015·Statistics in Medicine·Tong-Yu LuSiu Hung Cheung
Aug 12, 2014·Expert Opinion on Pharmacotherapy·Benjamin J VisserMartin P Grobusch
Apr 28, 2016·BMC Medical Research Methodology·Areti Angeliki VeronikiAndrea C Tricco
Mar 8, 2019·Statistical Methods in Medical Research·Tong-Yu LuSiu Hung Cheung
Aug 5, 2017·Malaria Journal·Solange Whegang YoudomLeonardo K Basco
Apr 9, 2021·BMC Infectious Diseases·Workineh ShibeshiEphrem Engidawork
May 23, 2021·Malaria Journal·Solange Whegang Youdom, Leonardo K Basco