Multiple treatment comparisons in a series of anti-malarial trials with an ordinal primary outcome and repeated treatment evaluations.

Malaria Journal
Solange Whegang YoudomJean-Christophe Thalabard

Abstract

Artemisinin-based combination therapies (ACT) are widely used in African countries, including Cameroon. Between 2005 and 2007, five randomized studies comparing different treatment arms among artesunate-amodiaquine and other ACT were conducted in Cameroonian children aged two to 60 months who had uncomplicated Plasmodium falciparum malaria. In these studies, the categorical criterion proposed by the World Health Organization (WHO) to assess the relative effectiveness of anti-malarial drugs was repeatedly evaluated on Days 14, 21 and 28 after treatment initiation. The aim of the present study was to compare the effects of different treatments on this repeated ordinal outcome, hence using the fully available information. The quantitative synthesis was based on individual patient data. Due to the incomplete block design concerning treatment arms between different trials, a mixed treatment comparison (MTC) meta-analysis approach was adopted. The repeated ordinal outcome was modelled through a latent variable, as a proportional odds mixed model with trial, period and treatment arms as covariates. The model was further complexified to account for the variance heterogeneity, and the individual log-residual variance was modelled as a l...Continue Reading

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Citations

Mar 8, 2014·Medicina clínica·Angel Domínguez-Castellano
Feb 18, 2016·Journal of Biopharmaceutical Statistics·Ping YangWai-Yin Poon
Aug 21, 2015·Statistics in Medicine·Tong-Yu LuSiu Hung Cheung
Aug 12, 2014·Expert Opinion on Pharmacotherapy·Benjamin J VisserMartin P Grobusch
Apr 28, 2016·BMC Medical Research Methodology·Areti Angeliki VeronikiAndrea C Tricco
Mar 8, 2019·Statistical Methods in Medical Research·Tong-Yu LuSiu Hung Cheung
May 23, 2021·Malaria Journal·Solange Whegang Youdom, Leonardo K Basco

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