PMID: 15247564Jul 13, 2004Paper

Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Jessica H OyugiDavid R Bangsberg

Abstract

There are no validated measures of adherence to HIV antiretroviral therapy in resource-poor settings. Such measures are essential to understand the unique barriers to adherence as access to HIV antiretroviral therapy expands. We assessed correspondence between multiple measures of adherence and viral load suppression in 34 patients purchasing generic Triomune antiretroviral therapy (coformulated stavudine, lamivudine, and nevirapine; CIPLA, Ltd., Mumbai, India) in Kampala, Uganda. Measures included 3-day patient self-report, 30-day visual analog scale, electronic medication monitoring, and unannounced home pill count. HIV-1 load was determined at baseline and 12 weeks. Mean adherence was 91%-94% by all measures. Seventy-six percent of subjects had a viral load of <400 copies/mL at 12 weeks. All measures were closely correlated with each other (R = 0.77-0.89). Each measure was also significantly associated with 12-week HIV load. There was no significant difference between patient-reported and objective measures of adherence. This sample of patients purchasing generic HIV antiretroviral therapy has among the highest measured adherence reported to date. Patient-reported measures were closely associated with objective measures. The...Continue Reading

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Citations

Apr 17, 2007·AIDS and Behavior·Mallory O Johnson, Torsten B Neilands
Sep 3, 2010·AIDS and Behavior·Jessica E HabererDavid R Bangsberg
Oct 19, 2010·AIDS and Behavior·Alexandra D MüllerCatherine Orrell
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