Multiple withdrawals from single-use vials: a study on sterility

International Journal of Pharmaceutics
Alba Ripoll GallardoFrancesco Della Corte

Abstract

Reutilization of single-use vials containing medical drugs is still under discussion. This practice has been adopted as a standard to avoid drug wastage, particularly in developing countries and in the aftermath of disasters. Some studies have assessed sterility of medications stored in single-use vials after utilization as multiple doses; however, most of these were limited to one single drug, included a low number of samples and did not consider an intermediate transfer step from the vial to a disposable syringe. The purpose of this study was to assess microbial contamination of samples withdrawn over three days from disposable syringes prepared from single-use vials. A prospective sterility study was conducted. A total of 600 initial samples were prepared from six-hundred 10 mL single-use vials of physiological solution into six-hundred 20 mL disposable syringes. Samples were prepared in three different standard operating rooms, on six different days and by the same operator, using basic sterile technique. All syringes were capped, placed together in a non-sterile steel container, covered with a clean drape and stored in the refrigerator at 4°C under non-sterile conditions. Using basic sterile technique, four samples were wi...Continue Reading

References

Aug 19, 2003·The Annals of Pharmacotherapy·Pamela D ReiterRobert J Valuck
Dec 13, 2006·Anaesthesia·S C HodgesI H Wilson
Sep 18, 2007·Journal of Clinical Anesthesia·Teoman Zafer ApanMehmet Cakirca
Sep 4, 2008·The Annals of Pharmacotherapy·Kemal OrnekOya Tekeli
Nov 6, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Cyril StuckiPascal Bonnabry
Sep 22, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Alan F MerryJohn H Eichhorn
Jan 9, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Shadi BaniasadiFanak Fahimi
Feb 25, 2014·Journal of Clinical Anesthesia·Anna WoodburyGrant C Lynde
Feb 26, 2014·Brazilian Journal of Anesthesiology·Ismail Aydin ErdenUlkü Aypar

❮ Previous
Next ❯

Citations

Jul 20, 2019·British Journal of Clinical Pharmacology·M G GopisankarCaleb Harris
Feb 14, 2018·Ocular Immunology and Inflammation·Chitaranjan MishraKim Ramasamy
Oct 7, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Victor M NeiraRichard I Hall
Nov 25, 2020·Ophthalmic Plastic and Reconstructive Surgery·Param BhatterJeremiah P Tao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Orthopaedics and Related Research
J P NelsonJ P McElhinney
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
S E WalkerB Schmidt
© 2021 Meta ULC. All rights reserved