Multiplex analysis of cytokines/chemokines as biomarkers that differentiate healthy contacts from tuberculosis patients in high endemic settings

Cytokine
D AnbarasuAlamelu Raja

Abstract

Differentiation of latent tuberculosis infection (LTBI) from active disease is one of the crucial elements in the control of tuberculosis. Earlier in Indian population which is tuberculosis endemic, we identified that 10 Mycobacterium tuberculosis secreted protein fractions, induced IFN-γ response only in healthy contacts of TB patients (HCs) and not in tuberculosis patients (TB). These fractions were termed as "Contact Specific Fractions" ("CS" fractions) and found useful for differentiating HC from TB. Proteomic analysis revealed that "CS" fractions have 16 different proteins, of which three were novel T cell antigens. Using these "CS" fractions as stimulants, earlier IFN-γ, TNF-α and IL-4 cytokine responses were studied. In the present study, in order to identify the other useful cytokine biomarkers that were differentially expressed between HC and TB, Cytokine/chemokine response to "CS" fractions were analyzed using multiplex cytokine assay system. This preliminary investigation in our tuberculosis endemic population showed six cytokine (G-CSF, IL-6, IL-7, IL-8, IL-9, and PDGF) and one receptor antagonist (IL-1Ra) that were differentially expressed between HC and TB, for the first time. Especially IL-6 and PDGF were more pr...Continue Reading

References

Jun 1, 1994·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·V H Springett, I Sutherland
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·N P JuffermansT van der Poll
Jul 24, 2002·The Journal of the Royal Society for the Promotion of Health·J M Grange, A Zumla
Dec 10, 2003·The Journal of Experimental Medicine·Robyn M KondrackLinda M Bradley
Sep 24, 2005·Infection and Immunity·Amy DavidowMaria L Gennaro
Apr 15, 2006·Science·Bruno Domon, Ruedi Aebersold
Jul 18, 2006·The Journal of Infectious Diseases·Matteo ZignolChristopher Dye
Apr 24, 2007·The Lancet Infectious Diseases·Sebastien Gagneux, Peter M Small
Nov 21, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sujatha NarayananKathryn Deriemer
Nov 23, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bo WuCarol Clayberger
Aug 8, 2008·The European Respiratory Journal·M RuhwaldUNKNOWN TBNET
Sep 10, 2008·Cell Host & Microbe·Stefan H E Kaufmann, Shreemanta K Parida
Sep 24, 2008·Seminars in Respiratory and Critical Care Medicine·Madhukar Pai, Richard O'Brien
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J J Waugh, Catherine Wilson
Nov 11, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Niyaz AhmedSeyed E Hasnain
Oct 27, 2009·Drug Discovery Today·Shreemanta K Parida, Stefan H E Kaufmann
Oct 27, 2009·Nature Reviews. Microbiology·Clifton E BarryDouglas Young
Jun 29, 2010·European Journal of Immunology·Akihiro Kimura, Tadamitsu Kishimoto
Jan 15, 2011·Clinical & Developmental Immunology·Suhail Ahmad
Apr 9, 2011·Nature Reviews. Immunology·Gerhard WalzlAlimuddin Zumla

❮ Previous
Next ❯

Citations

Jul 1, 2014·The Analyst·Nina Bergman, Jonas Bergquist
Oct 27, 2015·Journal of Immunology Research·Marcos Vinicius da SilvaCarlo Jose Freire Oliveira
Mar 10, 2015·Journal of Proteomics·Surekha M Zingde
Dec 3, 2014·Seminars in Immunology·Leticia Monin, Shabaana A Khader
Nov 9, 2016·Clinical Proteomics·Somaditya Mukherjee, Arun Bandyopadhyay
Sep 19, 2019·Infection and Immunity·Kathryn WrightKumudika de Silva
Mar 10, 2020·Pathogens and Disease·Elinor Hortle, Stefan H Oehlers
May 8, 2020·Journal of Immunology Research·Mariana HerreraZulma Vanessa Rueda
Dec 19, 2020·Cells·Kristina RitterChristoph Hölscher
Jul 3, 2021·Vaccines·Matthieu Van TilbeurghCaroline Manet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Respirology : Official Journal of the Asian Pacific Society of Respirology
Chang-Min ChoiJae-Joon Yim
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Ji Young HongYoung Ae Kang
© 2021 Meta ULC. All rights reserved