Abstract
Seminal fluid is known to be responsible for orchestrating mating-induced immunomodulation. Central to this process are numerous cytokines that modulate uterine leukocyte recruitment and trafficking. Despite this, a comprehensive analysis of the cytokine profile of murine seminal fluid is lacking. This study addressed this issue by using multiplex immunoassays to characterise the profile of interleukin (IL)-1alpha , IL-1beta , IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-17, eotaxin, granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), interferon (IFN)-gamma, keratinocyte-derived chemokine (KC), monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha , MIP-1beta , regulated upon activation normal T-cell expressed and secreted (RANTES), and tumour necrosis factor (TNF)-alpha in fluid drawn from the seminal vesicles of single mice (n = 18). Their levels and ratios were compared with those found in serum. IL-1alpha , IL-1beta , IL-2, IL-5, IL-9, IL-12 (p40), IL-12 (p70), IL-13, IL-17, GM-CSF, IFN-gamma, MCP-1 and TNF-alpha levels were significantly higher in serum; IL-4, G-CSF, eotaxin, KC and RANTES exhibited the ...Continue Reading
References
Jun 1, 1992·Biology of Reproduction·S A RobertsonR F Seamark
Jul 1, 1988·Journal of Reproductive Immunology·S SaxenaA Farooq
May 1, 1985·Journal of Reproduction and Fertility·E Koch, F Ellendorff
May 1, 1984·Cellular Immunology·J S HuntG W Wood
Apr 1, 1995·American Journal of Reproductive Immunology : AJRI·M Nocera, T M Chu
Sep 1, 1993·Andrologia·Z G LiangS S Koide
Jul 1, 1995·Archives of Andrology·R K Naz, E R Stanley
Nov 1, 1995·American Journal of Reproductive Immunology : AJRI·K ShimoyaO Tanizawa
Aug 1, 1996·Fertility and Sterility·T M ChuE Kawinski
May 1, 1996·Journal of Reproductive Immunology·D MiaoK James
Jan 1, 1996·Biology of Reproduction·S A RobertsonR F Seamark
Jul 1, 1996·Journal of Reproduction and Fertility·S A RobertsonR F Seamark
Jan 1, 1997·Molecular Reproduction and Development·G W WoodR Choudhuri
Mar 1, 1997·The Journal of Clinical Investigation·A W MouldP S Foster
Apr 1, 1997·Human Reproduction·R W KellyH O Critchley
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·S A RobertsonK P Tremellen
Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·J E HallE W Shek
Mar 24, 1998·Urology·M FujisawaS Kamidono
May 16, 1998·Archives of Andrology·M FujisawaS Kamidono
May 29, 1998·Biology of Reproduction·K P TremellenS A Robertson
Jul 1, 1998·International Reviews of Immunology·F FossiezS Lebecque
Nov 7, 1998·Archives of Andrology·I MatalliotakisE Koumantakis
Nov 7, 1998·Archives of Andrology·G FrenetteM Lemay
Mar 9, 1999·International Journal of Andrology·R W Kelly
May 20, 1999·Molecular Human Reproduction·F C DenisonR W Kelly
Jun 8, 1999·Annual Review of Immunology·M Wills-Karp
Oct 20, 1999·Andrologia·M HuleihelM Glezerman
Mar 9, 2000·Journal of Reproductive Immunology·S A RobertsonR F Seamark
Sep 15, 2000·Journal of Immunological Methods·D A Vignali
Nov 15, 2000·American Journal of Reproductive Immunology : AJRI·R K Naz, M H Leslie
May 4, 2001·Journal of Reproductive Immunology·M MaccioniV E Rivero
Jul 5, 2001·Seminars in Immunology·S A Robertson, D J Sharkey
Feb 13, 2002·Journal of Reproductive Immunology·Masahiko MaegawaToshihiro Aono
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Umit A KayisliAydin Arici
Nov 22, 2002·American Journal of Reproductive Immunology : AJRI·Ioannis MatalliotakisEvgenios Koumantakis
Dec 4, 2002·European Journal of Haematology·Eirunn KnudsenHaakon Breien Benestad
Aug 5, 2003·Journal of Reproductive Immunology·Sarah A RobertsonKelton P Tremellen
Sep 26, 2003·American Journal of Reproductive Immunology : AJRI·Kenji SugitaTatsuo Yamamoto
Nov 14, 2003·Molecular Human Reproduction·S GutscheC J Thaler
Feb 5, 2004·Journal of Andrology·Sarmistha BasuNancy L Brackett
May 19, 2004·Immunology·Martina JohanssonSarah A Robertson
Jul 28, 2004·Immunology Letters·Wenji SunXuetao Cao
Jul 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·S O'LearyS A Robertson
Aug 4, 2004·Journal of Reproductive Immunology·Silvia DaherRosiane Mattar
Oct 21, 2004·Journal of Perinatal Medicine·Corrina PowellMalcolm Levene
Apr 12, 2005·Cell·Yoshiki SekijimaJeffery W Kelly
Jul 28, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Xinmei ZhangLin Deng
Sep 1, 2005·Chemical Immunology and Allergy·Marie-Pierre Piccinni
Citations
Jul 18, 2012·Bulletin of Experimental Biology and Medicine·M A SteninaV N Yarygin
Oct 19, 2013·Bulletin of Experimental Biology and Medicine·M A SteninaV N Yarygin
Jan 24, 2008·Immunologic Research·Matthew M Seavey, Tim R Mosmann
Dec 20, 2012·PloS One·Deepika JaiswalKiran Singh
Jun 7, 2013·BioResearch Open Access·Rebecca L R PowellGavin Morrow
Dec 17, 2008·Human Fertility : Journal of the British Fertility Society·Nicolas Michel Orsi
Sep 27, 2013·Systems Biology in Reproductive Medicine·Deepika JaiswalKiran Singh
Sep 29, 2015·American Journal of Reproductive Immunology : AJRI·Isabel BarrancoHeriberto Rodriguez-Martinez
Jan 13, 2009·Animal Reproduction Science·Ulrike TaylorHans-Joachim Schuberth
Apr 24, 2007·Journal of Reproductive Immunology·Nicolas M OrsiJames J Walker
Feb 13, 2008·Journal of Neuroendocrinology·N M Orsi, R M Tribe
Nov 20, 2010·American Journal of Reproductive Immunology : AJRI·Kotaro Kitaya, Hisao Yamada
Nov 23, 2006·Theriogenology·Nicolas M Orsi, Judith B Reischl
Sep 12, 2006·Animal Reproduction Science·Nicolas M OrsiNadia Gopichandran
Jun 27, 2015·Journal of Medical Virology·Marcia L ShewDarron R Brown
Apr 26, 2016·Scientific Reports·Zhi-Hui SongJing-Pian Peng
Mar 20, 2015·Reproduction, Fertility, and Development·Jin-Hua WeiZhen Li
Oct 25, 2013·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jane Christopher-HenningsJoan K Lunney
Oct 6, 2015·Reproduction, Fertility, and Development·Ludmila A GerlinskayaMikhail P Moshkin
Jul 15, 2015·Biology of Reproduction·John E SchjenkenSarah A Robertson
Mar 30, 2018·Biology of Reproduction·David J SharkeySarah A Robertson
Dec 1, 2017·PloS One·Michelle L JohnsonNicolas M Orsi
Nov 9, 2017·Journal of Cellular Physiology·Cristina B HebedaSandra H P Farsky
Jun 15, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rong-Dih LinMei-Hsien Lee
Jan 31, 2020·Physiological Reviews·John E Schjenken, Sarah A Robertson
Mar 20, 2008·Animal Health Research Reviews·Jane Christopher-HenningsJoan Lunney
Dec 24, 2019·Frontiers in Veterinary Science·Isabel BarrancoInmaculada Parrilla
Apr 29, 2021·Andrologia·Marziyeh AjdaryMehdi Mehdizadeh
Jun 26, 2021·Endocrinology·John E SchjenkenSarah A Robertson
Jan 20, 2021·ACS Biomaterials Science & Engineering·Yi LiuZ G Wang
Oct 10, 2021·BMC Genomics·David A Skerrett-ByrneJohn E Schjenken