Multiplex genotyping as a biomarker for susceptibility to carcinogenic exposure in the FLEHS biomonitoring study

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Hans B KetelslegersJos C S Kleinjans

Abstract

Cancer has been suggested to result from interactions between genetic and environmental factors, and certain subgroups in the general population may be at increased risk because of their relatively higher susceptibility to environmental carcinogens. The current study, part of a large biomonitoring study conducted in Flanders from 2002 to 2006 (The Flanders Environment and Health Survey), aims to determine these susceptible subpopulations based on multiple genotypic differences between individuals. A random selection of 429 adolescents and 361 adults was genotyped for 36 polymorphisms in 23 genes selected because of their known role in carcinogen metabolism, DNA repair, and oxidative stress. In both age groups, relationships between endogenous exposure to organochloride substances (polychlorinated biphenyl, hexachlorobenzene, dichlorodiphenyl dichloroethane), metals (cadmium, lead), and urinary metabolites (1-hydroxypyrene, trans-trans muconic acid) versus genotoxic effects (Comet assay and micronuclei in lymphocytes, and urinary 8-hydroxydeoxyguanosine) were investigated. In addition, in the study among adults, the relationship of these exposures with several tumor markers (prostate-specific antigen, carcinoembryonic antigen, a...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Sep 1, 1993·Carcinogenesis·F CroftsS J Garte
Apr 17, 1996·Journal of the National Cancer Institute·F P Perera
Jan 1, 1996·Methods in Enzymology·K KawajiriS Hayashi
Sep 26, 1997·Nature·K PolyakB Vogelstein
Nov 14, 1997·Science·F P Perera
Mar 27, 1999·Archives of Environmental Health·M SalaJ Grimalt
Jul 1, 1999·Molecular Aspects of Medicine·A R Collins
May 16, 2000·Occupational and Environmental Medicine·Y C HongE H Ha
Sep 6, 2000·Pharmacology·J D Hayes, R C Strange
Dec 13, 2000·Mutation Research·M Fenech
Feb 5, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·B GómaraM J González
Apr 18, 2003·Toxicology·K DanadeviParamjit Grover
May 15, 2003·International Journal of Environmental Health Research·Nik van LarebekeEric Pluygers
Jun 17, 2003·Chemical Research in Toxicology·Janine EzendamRaymond Pieters
Jul 2, 2003·Nature Genetics·Cynthia T McMurray, John A Tainer
Nov 25, 2004·Chemico-biological Interactions·Kaoru MidorikawaNakao Kojima
Mar 19, 2005·American Journal of Industrial Medicine·Ali Esat KarakayaSemra Sardas
Sep 30, 2005·American Journal of Epidemiology·Jiyoung AhnChristine B Ambrosone
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hans B KetelslegersJoost H M van Delft
May 12, 2006·Critical Reviews in Toxicology·E Mariussen, F Fonnum
May 30, 2006·Toxicology·Jianxun Xie, Zahir A Shaikh

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Citations

Oct 7, 2011·Environmental Health : a Global Access Science Source·Hans B KetelslegersNicolas A van Larebeke
Dec 6, 2014·Mutation Research. Reviews in Mutation Research·Peter MøllerSteffen Loft
Nov 24, 2012·International Journal of Cancer. Journal International Du Cancer·Arash EtemadiFrederik J van Schooten
Nov 5, 2013·Mutation Research. Reviews in Mutation Research·Andrew CollinsUNKNOWN ComNet project
Feb 1, 2012·Journal of Toxicology·Nitchaphat KhansakornJintana Sirivarasai
Oct 4, 2016·International Journal of Hygiene and Environmental Health·Hans ReyndersKaren Van Campenhout
Oct 25, 2016·Environmental Research·Carmen FrankenGreet Schoeters
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fang WangTangchun Wu

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