Multiplex immunoassay measurement of amyloid-β42 to amyloid-β40 ratio in plasma discriminates between dementia due to Alzheimer's disease and dementia not due to Alzheimer's disease

Experimental Brain Research
Jonathan VogelgsangJens Wiltfang

Abstract

The cerebrospinal fluid (CSF) biomarkers amyloid-β42 (Aβ42), total Tau, and phospho-181-Tau represent important diagnostic tools to support the clinical diagnosis of Alzheimer's disease (AD). Acquiring CSF by lumbar puncture is considered a moderately invasive procedure, while blood sampling is minimally invasive with calculable risks and can be performed by trained non-medical staff. Thus, the identification of reliable and robust blood biomarkers of AD-related neuropathology would be significantly advantageous in daily practice and would allow more patients to be screened. In this study, we performed a multiplex amyloid-β assay to simultaneously measure Aβ40 and Aβ42. We analyzed how well Aβ40, Aβ42, and the Aβ42 to Aβ40 ratio (Aβ42/40) could differentiate between patients suffering from dementia either due or not due to AD. In addition, we studied different factors affecting Aβ levels in plasma. Plasma Aβ42/40 level was significantly lower in patients with dementia due to AD than in those with dementia due to other causes. Aβ42/40 correlated weakly between plasma and CSF, but did not differ between amyloid-PET positive or negative patients. Furthermore, we found that kidney function influences Aβ40 and Aβ42 plasma levels, bu...Continue Reading

References

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Citations

May 5, 2018·Scientific Reports·Kevin J CaoJerry Yang
Jan 18, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Emily G Jackson, Sarah Stowe
Sep 28, 2018·Nature Neuroscience·Suzanne HickmanJoseph El Khoury
Apr 20, 2019·Pharmacological Reports : PR·Habiba Rashid, Touqeer Ahmed
Jul 28, 2020·Antioxidants·Carmen Peña-BautistaConsuelo Cháfer-Pericás
Feb 16, 2019·Journal of Neural Transmission·Joana R F SantosJonathan Vogelgsang
Aug 14, 2019·Der Nervenarzt·Jonathan Vogelgsang, Jens Wiltfang
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Tânia Soares MartinsAna Gabriela Henriques
Oct 3, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Xue-Ning ShenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 6, 2020·Journal of Alzheimer's Disease : JAD·Marlena WalterJonathan Vogelgsang
Oct 13, 2020·Journal of Alzheimer's Disease : JAD·Melanie HüttenrauchSusana Castro-Obregón
Jan 25, 2021·Alcoholism, Clinical and Experimental Research·Julien AzuarFrank Questel

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Methods Mentioned

BETA
immunoprecipitation
PCR
blood

Software Mentioned

Mesoscale
Quanterix

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