PMID: 6160831Jan 1, 1980Paper

Multiplication and distribution of Aujeszky's disease (pseudorabies) virus in vaccinated and non-vaccinated pigs after intranasal infection

Archives of Virology
G WittmannR Ahl

Abstract

The primary sites of Aujeszky's disease virus (ADV) multiplication in intranasally (i.n.) infected pigs were found to be in the nasopharyngeal, tracheal and pulmonary regions. From the second day post infection (DPI) onward ADV invaded the central nervous system and other organs. The virus was isolated from the nasopharyngeal region for at least 2 weeks. In serum ADV was present with low levels from DPI 1 to DPI 7. In pigs vaccinated with an inactivated vaccine and then challenged the distribution of ADV was rather similar to that in non-vaccinated animals, in spite of the presence of neutralizing antibodies. The virus titres in the organs generally were lower than in non-vaccinated animals up to DPI 7. Thereafter, titre differences were no longer significant. Virus was isolated from the tonsils and the lungs for at least 2 weeks. Interferon production in vaccinated infected pigs was significantly lower than in non-vaccinated infected pigs. Though multiplication and dissemination of ADV occurred, vaccinated pigs did not show clinical symptoms of Aujeszky's disease. Traces of ADV were detected in a small percentage of white blood cells (WBC) of non-vaccinated infected pigs. ADV was isolated from the lymphocyte-enriched and polym...Continue Reading

References

Sep 1, 1976·Infection and Immunity·R Ahl, A Rump
Jan 1, 1979·Archives of Virology·L A AshworthA Baskerville
Jun 1, 1975·Clinical Pharmacology and Therapeutics·M M LeWinterR A ORourke
Jul 1, 1973·The Journal of General Virology·R M McCrackenC Dow

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Citations

Jan 15, 1992·Veterinary Immunology and Immunopathology·S Chinsakchai, T W Molitor
Oct 1, 1994·Veterinary Immunology and Immunopathology·S Chinsakchai, T W Molitor
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E AlbinaB Charley
Mar 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R WongwatcharadumrongT Linné
Mar 1, 1995·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M FerrariP Bergonzini
Sep 9, 2005·Microbiology and Molecular Biology Reviews : MMBR·Lisa E PomeranzChristoph J Hengartner
Mar 10, 1998·The Journal of Veterinary Medical Science·S KatayamaY Shimizu
Apr 19, 2015·Virology Journal·Letian ZhangYanli Lyu
Jul 1, 2016·BMC Veterinary Research·V MilicevicV Radosavljevic
Nov 1, 1989·Microbial Pathogenesis·J M PolJ T van Oirschot
Jul 18, 2018·Transboundary and Emerging Diseases·Yaowalak PanyasingRoongroje Thanawongnuwech
Sep 1, 1987·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·S BelákT Linné
Oct 24, 2003·The Journal of General Virology·Herman W FavoreelMaurice B Pensaert
Feb 27, 2003·The Journal of General Virology·Gerlinde R Van de WalleMaurice B Pensaert
Oct 1, 1982·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A ZuffaK Cerník
Mar 13, 1999·The Veterinary Record·G M Rodríguez-ArriojaM Domingo
May 1, 1997·The Veterinary Journal·K C Smith

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