Multiplicity of hypoxia-inducible transcription factors and their connection to the circadian clock in the zebrafish

Physiological and Biochemical Zoology : PBZ
Bernd Pelster, Margit Egg

Abstract

In zebrafish, as in most vertebrates, three different isoforms of the hypoxia-inducible transcription factor, Hif-1α, Hif-2α, and Hif-3α, have been identified. The expression data of genes encoding these three proteins, as analyzed so far, show distinct expression patterns for all three isoforms during early development, under hypoxic conditions, and during exercise, suggesting differential roles for all three proteins under these different conditions. While isoform-specific functions for Hif-1α and Hif-2α have been identified in recent years, the role of Hif-3α remains somewhat elusive. Several studies mostly using mammalian cells or tissues discussed Hif-3α as a competitive inhibitor of Hif-1α and Hif-2α. In zebrafish, the expression changes for Hif-1α and Hif-3α observed during development and under environmental stress conditions do not support this hypothesis, and recent studies indicate that Hif-3α is also able to directly control transcriptional activity of certain genes. The Hif signaling pathway is tightly connected to cell circuitries such as glucose and lipid metabolism, and only very recently a further linkage to the circadian clock has been described. In this context a detailed analysis of the mRNA concentrations o...Continue Reading

References

Jan 1, 1991·Annual Review of Physiology·W W Burggren, A W Pinder
Aug 15, 1998·Biochemical and Biophysical Research Communications·S TakahataY Fujii-Kuriyama
Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B Pelster
Mar 15, 2001·Current Opinion in Cell Biology·G L Semenza
Jul 20, 2002·The Journal of Biological Chemistry·Estela MuñozRuben Baler
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Asha JacobNajma Begum
Oct 17, 2003·High Altitude Medicine & Biology·Gerardo BoscoJacopo P Mortola
Apr 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mikko Nikinmaa, Bernard B Rees
Dec 20, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jørund SollidGöran E Nilsson
Jul 1, 2006·The Journal of Experimental Biology·Jimmy C C LaiDavid Randall
Sep 26, 2006·Gene Expression Patterns : GEP·Diego A RojasAriel E Reyes
May 8, 2007·Cell·Brian Keith, M Celeste Simon
May 24, 2008·Molecular Cell·William G Kaelin, Peter J Ratcliffe
Mar 3, 2009·The Journal of Experimental Biology·Peter Rombough, Holly Drader
Mar 17, 2009·PloS One·Katarzyna BozekHanspeter Herzel
Sep 17, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Catherine E ForristalFranchesca D Houghton
Oct 28, 2009·PLoS Biology·Gad VatineNicholas S Foulkes
Apr 27, 2010·The International Journal of Biochemistry & Cell Biology·Annika PasanenJohanna Myllyharju
Jul 10, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Rui-Jie ShenShu-Ming Zou
Sep 3, 2010·Annual Review of Genetics·Colleen J Doherty, Steve A Kay
Nov 27, 2010·EMBO Reports·Kalle T Rytkönen, Jay F Storz
Nov 16, 2012·Nature·Joseph Bass
Jan 11, 2013·Physiological Reviews·Kristin Eckel-Mahan, Paolo Sassone-Corsi
Mar 7, 2013·Evolution; International Journal of Organic Evolution·Kalle T RytkönenMikko Nikinmaa
Nov 23, 2013·Nature Reviews. Cancer·David C BerstenMurray L Whitelaw

❮ Previous
Next ❯

Citations

Mar 21, 2016·Fish Physiology and Biochemistry·R B BaptistaV M F Almeida-Val
Mar 17, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Fengmei Li, Wuyi Liu
Nov 6, 2018·Frontiers in Endocrinology·Mouna TabebiLasse D Jensen
Jul 30, 2020·American Journal of Physiology. Cell Physiology·Emma J O'ConnellKristina M Cook
Aug 24, 2018·The Journal of Experimental Biology·Jenni M Prokkola, Mikko Nikinmaa
Jan 17, 2021·Experimental Gerontology·Zhuoying ChenXiangjie Liu
May 13, 2020·Trends in Endocrinology and Metabolism : TEM·Clara B Peek
Feb 21, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·You-Wu DaiJiong Chen
Mar 24, 2021·Cell Communication and Signaling : CCS·Zhen ZhangXuefei Tian
Jun 25, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jing WangWeijie Mu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.