Multipoint oligogenic linkage analysis of quantitative traits

Genetic Epidemiology
J Blangero, L Almasy

Abstract

We present an overview of pedigree-based variance component linkage methods and discuss their extension to oligogenic inheritance. As an example, oligogenic linkage analyses were performed using the quantitative trait Q4 from the GAW10 simulated data set. A strategy involving sequential oligogenic analyses was found to have increased power to detect the three quantitative trait loci (QTL) influencing Q4 when compared to the classical marginal approach of requiring each locus to have a lod score > or = 3. However, it is shown that requiring conditional lod scores > or = 3 in the sequential analyses may be overly conservative and alternative criteria for the acceptance of multilocus models are discussed.

References

Jan 1, 1988·Genetic Epidemiology·K LangeM Boehnke
Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston
Dec 1, 1996·Genome Génome / Conseil National De Recherches Canada·C S EchtR Zahorchak

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Citations

Jan 22, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·V Saroja VorugantiAnthony G Comuzzie
May 17, 2000·Biological Psychiatry·W H KayeC W McConaha
Jun 2, 1998·Electroencephalography and Clinical Neurophysiology·H BegleiterF E Bloom
Dec 12, 2002·Urologic Oncology·Rosemarie PlaetkeNedal H Arar
Dec 15, 2010·European Journal of Human Genetics : EJHG·Manuel A R FerreiraNicholas G Martin
Oct 31, 2008·Heredity·D L RainwaterM C Mahaney
Nov 30, 2006·European Journal of Human Genetics : EJHG·Simona BarleraUNKNOWN PROCARDIS Consortium
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·N E Morton, A Collins
Nov 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey BethonyPeter J Hotez
Apr 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nedal H ArarHanna E Abboud
Oct 31, 2013·BioMed Research International·D M SantosJ A Maia
Jun 4, 2008·The Journal of Clinical Investigation·Wei-Min ChenRichard M Watanabe
Feb 21, 2004·BMC Genetics·Stephanie R BeckCarl D Langefeld
Feb 3, 2006·BMC Genetics·Aurélie Labbe, Hanna Wormald
Jun 14, 2006·BMC Genetics·Heping Zhang, Xiaoyun Zhong
Feb 3, 2004·Journal of Lipid Research·Gabriele E SonnenbergAhmed H Kissebah
Nov 13, 2008·The Journal of Clinical Endocrinology and Metabolism·V Saroja VorugantiNedal H Arar
Jul 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Yu-Hsiang ShuRichard M Watanabe
Apr 17, 2009·Journal of the American Society of Nephrology : JASN·Amy K MottlKari E North
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Marina ScaviniPhilip G Zager
Apr 2, 2014·Calcified Tissue International·Nerea Hernandez-de SosaJordi Casademont
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A H KissebahA G Comuzzie
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rui FengHeping Zhang
Jan 17, 2016·Computers in Biology and Medicine·Miquel Vázquez-SantiagoJuan Carlos Souto
Mar 31, 2015·NeuroImage·Habib GanjgahiThomas E Nichols
Oct 16, 2008·Kidney International·Amy K MottlKari E North
Mar 15, 2002·Chest·Edwin K Silverman
Jul 22, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jean W MacCluerPhilip G Zager
Feb 18, 2015·Source Code for Biology and Medicine·Robert V BaronDaniel E Weeks
Apr 20, 2004·Obesity Research·Lisa J MartinAnthony G Comuzzie
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Candace M KammererBraxton D Mitchell
Mar 12, 2009·Genetic Epidemiology·Josée DupuisDavid Siegmund

❮ Previous
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