Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration

Stem Cells International
Jeffrey ZeckserJosh Goodwin

Abstract

Low back pain with resultant loss of function, decreased productivity, and high economic costs is burdensome for both the individual and the society. Evidence suggests that intervertebral disc pathology is a major contributor to spine-related pain and degeneration. When commonly used conservative therapies fail, traditional percutaneous or surgical options may be beneficial for pain relief but are suboptimal because of their inability to alter disc microenvironment catabolism, restore disc tissue, and/or preserve native spine biomechanics. Percutaneously injected Multipotent Mesenchymal Stem Cell (MSC) therapy has recently gained clinical interest for its potential to revolutionarily treat disc-generated (discogenic) pain and associated disc degeneration. Unlike previous therapies to date, MSCs may uniquely offer the ability to improve discogenic pain and provide more sustained improvement by reducing disc microenvironment catabolism and regenerating disc tissue. Consistent treatment success has the potential to create a paradigm shift with regards to the treatment of discogenic pain and disc degeneration.

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Citations

Jan 10, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael D NewtonTristan Maerz
Mar 2, 2017·Stem Cells International·Mingjie WangQuanyi Guo
Jul 31, 2019·Current Pain and Headache Reports·Ivan UritsVwaire Orhurhu
Jun 4, 2019·Global Spine Journal·Hans-Joerg MeiselZorica Buser
May 23, 2020·Clinical Neurology and Neurosurgery·Yagiz Ugur YolcuMohamad Bydon
Dec 4, 2019·The Journal of the American Osteopathic Association·Derek Buck
Aug 17, 2021·BioMed Research International·Dong-Duo QiYu-Feng Huang

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Methods Mentioned

BETA
transdiscal biaculoplasty

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