Multipronged Biomimetic Approach To Create Optically Tunable Nanoparticles

Angewandte Chemie
Kara M HarmatysGang Zheng

Abstract

Current biomimetics for medical applications use a single biomimetic approach to imitate natural structures, which can be insufficient for reconstructing structurally complex natural systems. Multipronged efforts may resolve these complexities. To achieve interesting nanostructure-driven optical properties, a dual-biomimetic system contained within a single nanoagent was engineered to recapitulate chlorosomes, efficient light-harvesting organelles that have unique dye assemblies and tunable photonic properties. A series of chlorin dyes was synthesized, and these hydrophobic assemblies were stabilized inside a high-density lipoprotein, a second biomimetic that enabled in vivo utility. This system resulted in tunable tumor imaging of intact (photoacoustic) and disrupted (activatable fluorescence) nanostructures. The successful demonstration of this multipronged biomimetic approach opens the door for reconstruction of complex natural systems for biomedical applications.

References

Oct 23, 2008·Nano Letters·David P CormodeWillem J M Mulder
Oct 31, 2009·Angewandte Chemie·Zhihong ZhangGang Zheng
Jul 2, 2011·Nature Reviews. Drug Discovery·Jin-Wook YooSamir Mitragotri
Jul 20, 2013·Accounts of Chemical Research·Sanchita Sengupta, Frank Würthner
Jan 24, 2015·Nano Letters·Weiwei GaoLiangfang Zhang
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Sep 26, 2017·Biomaterials·Alessandro ParodiEnnio Tasciotti
Oct 20, 2017·Chemical Society Reviews·M A RajoraG Zheng

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Citations

Jul 31, 2019·Biomedical Optics Express·Sangheon HanKonstantin V Sokolov
Apr 26, 2019·Accounts of Chemical Research·Kara M HarmatysGang Zheng
Dec 6, 2019·ACS Applied Materials & Interfaces·Behzad ChangalvaieKeith P Johnston

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