Multiregional Age-Associated Reduction of Brain Neuronal Reserve Without Association With Neurofibrillary Degeneration or β-Amyloidosis

Journal of Neuropathology and Experimental Neurology
J WegielThomas Wisniewski

Abstract

Increase in human life expectancy has resulted in the rapid growth of the elderly population with minimal or no intellectual deterioration. The aim of this stereological study of 10 structures and 5 subdivisions with and without neurofibrillary degeneration in the brains of 28 individuals 25-102-years-old was to establish the pattern of age-associated neurodegeneration and neuronal loss in the brains of nondemented adults and elderly. The study revealed the absence of significant neuronal loss in 7 regions and topographically selective reduction of neuronal reserve over 77 years in 8 brain structures including the entorhinal cortex (EC) (-33.3%), the second layer of the EC (-54%), cornu Ammonis sector 1 (CA1) (-28.5%), amygdala, (-45.8%), thalamus (-40.5%), caudate nucleus (-35%), Purkinje cells (-48.3%), and neurons in the dentate nucleus (40.1%). A similar rate of neuronal loss in adults and elderly, without signs of accelerating neuronal loss in agers or super-agers, appears to indicate age-associated brain remodeling with significant reduction of neuronal reserve in 8 brain regions. Multivariate analysis demonstrates the absence of a significant association between neuronal loss and the severity of neurofibrillary degenerat...Continue Reading

References

Jan 1, 1977·Archives of Neurology·P L McGeerJ S Suzuki
Aug 1, 1977·Cell Differentiation·S Chatterjee
Apr 1, 1992·Journal of the Neurological Sciences·T Mizutani, H Shimada
Apr 21, 1990·Lancet·C D Marsden
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jan 1, 1990·Neurobiology of Aging·O J VogelsB P Schulte
Jun 1, 1990·The Journal of Comparative Neurology·M J West, H J Gundersen
Oct 1, 1989·Annals of Neurology·D SchermanY Agid
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Oct 1, 1980·Archives of Neurology·A G Herzog, T L Kemper
Nov 1, 1993·Trends in Neurosciences·H C LeinerR S Dow
May 1, 1995·The Journal of Comparative Neurology·R InsaustiL M Gonzalo
Sep 28, 1995·Nature·L CahillJ L McGaugh
Jan 1, 1994·Acta Neuropathologica·H BraakK Jellinger
Jan 1, 1994·Neurobiology of Aging·T H VereeckenR Nieuwenhuys
Jul 1, 1993·Neurobiology of Aging·M J West
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·M Davis
Aug 1, 1997·The Gerontologist·J W Rowe, R L Kahn
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Jul 1, 1997·Neurobiology of Aging·W SilvermanJ Wegiel
Sep 25, 1998·Neurology·A F Jorm, D Jolley
Feb 24, 1999·Journal of Neuropathology and Experimental Neurology·R MorschP D Coleman
Mar 14, 2000·International Journal of Geriatric Psychiatry·B A BlansjaarH W Van Schaick
May 11, 2000·Acta Neuropathologica·L Korbo, M West
May 11, 2000·Acta Neuropathologica·G GoldP Giannakopoulos
Jul 11, 2001·Neurobiology of Aging·T L JerniganJ R Hesselink
Sep 18, 2001·Archives of Neurology·J L PriceJ C Morris
Oct 9, 2001·Journal of Neuropathology and Experimental Neurology·G GoldP Giannakopoulos
Jan 25, 2002·Annals of the New York Academy of Sciences·D Harman

❮ Previous
Next ❯

Citations

Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Eleanor DrummondThomas Wisniewski
Feb 15, 2018·Journal of Alzheimer's Disease : JAD·Laura MahadyElliott J Mufson
Jun 20, 2018·Alzheimer's Research & Therapy·Krystal HerlineThomas Wisniewski
Jan 29, 2019·Frontiers in Systems Neuroscience·Naomi HartoppMichael J O'Sullivan
Dec 4, 2020·Journal of Neuropathology and Experimental Neurology·Jerzy WegielBarry Reisberg
Apr 4, 2021·Genes·Eun-Mi Hur, Byoung Dae Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.