PMID: 11336335May 5, 2001Paper

Multiresidue determination of organophosphorus and organochlorine pesticides in human biological fluids by capillary gas chromatography

Fresenius' Journal of Analytical Chemistry
E PitarchF Hernández

Abstract

Two multiresidue analytical methods for the simultaneous determination of organophosphorus and organochlorine pesticides in human urine and serum samples are described. The first approach is based on liquid-liquid microextraction with dichloromethane, and the second uses solid-phase extraction with C18. In both methods, the extracts are analyzed by capillary gas chromatography using nitrogen-phosphorus detection (NPD) and electron-capture detection (ECD). Limits of detection of the overall procedure of analysis are at the low ng mL(-1) level. Stability experiments have been performed with spiked urine and serum samples stored at 4 degrees C for 1 month. Finally, the solid-phase extraction procedure was applied to real-world samples. Quantification was performed by NPD or ECD, and peak identity was confirmed by use of mass-selective detection (MSD).

Citations

Aug 2, 2011·Environmental Monitoring and Assessment·Samim OzenTahir Gurler
Jun 7, 2015·Journal of Forensic and Legal Medicine·Nuno I P ValenteHelena M Teixeira
May 28, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Warangkana NaksenParinya Panuwet
Oct 14, 2005·Molecular and Cellular Endocrinology·Mandana Ghisari, Eva C Bonefeld-Jorgensen
Apr 10, 2007·Therapeutic Drug Monitoring·Maria G MargaritiAristidis M Tsatsakis
Feb 14, 2006·Rapid Communications in Mass Spectrometry : RCM·E GallardoM López-Rivadulla
Jul 13, 2019·International Journal of Legal Medicine·Sofia SoaresEugenia Gallardo

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