Multiresidue determination of sulfonamide antibiotics in milk by short-column liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
D Volmer

Abstract

Liquid chromatography coupled to electrospray mass spectrometry and tandem mass spectrometry has been used for the determination and quantification of 21 sulfonamides and two potentiators (ormethoprim, trimethoprim) in milk. Separation using high-performance liquid chromatography was achieved in less than 6 min for all compounds on a short (4.0 x 50 mm, 3 micron) reversed-phase column. After sample clean-up, time-scheduled single-ion monitoring (SIM) yielded detection of sulfonamides in milk from low ppb level to the ppt level. The strategy used to detect, confirm and quantify sulfonamides in milk samples was as follows: (a) pre-screening (and cp3firmation) of target and non-target sulfonamides by precursor ion scan and/or multiple reaction monitoring experiments using generic product ions; (b) quantification of identified target compounds by monitoring their protonated molecule ions in a time-scheduled SIM experiment; (c) further confirmation, if necessary, by selected reaction monitoring using characteristic product ions.

Citations

Jul 9, 2004·Critical Reviews in Food Science and Nutrition·Stamatia I Kotretsou
Sep 25, 2010·Chemosphere·Jette SchwarzSören Thiele-Bruhn
May 29, 2003·Rapid Communications in Mass Spectrometry : RCM·Katerina KlagkouG John Langley
Oct 31, 2003·Rapid Communications in Mass Spectrometry : RCM·Katerina KlagkouG John Langley
Mar 17, 2009·Analytica Chimica Acta·A F Forti, G Scortichini
Nov 12, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kamila Mitrowska, Maja Antczak
Nov 10, 2000·The Journal of Veterinary Medical Science·E KoJ H Park
Jul 11, 2001·Rapid Communications in Mass Spectrometry : RCM·J MorganD Lloyd
Feb 12, 2000·Rapid Communications in Mass Spectrometry : RCM·N Van EeckhoutC Van Peteghem
Mar 21, 2003·Protein Engineering·Teemu KorpimäkiPetri Saviranta
Aug 6, 1998·Journal of Chromatography. a·W M Niessen
Apr 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·B ChiavarinoS Fornarini
Jun 8, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David N HellerMichael H Thomas
Mar 29, 2014·Journal of the American Society for Mass Spectrometry·Jason B BialeckiAthula B Attygalle
Mar 13, 2015·Journal of the American Society for Mass Spectrometry·Renata KobetićBiserka Žinić

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