Multiscale examination of cytoarchitectonic similarity and human brain connectivity

Network Neuroscience
Yongbin WeiMartijn P van den Heuvel

Abstract

The human brain comprises an efficient communication network, with its macroscale connectome organization argued to be directly associated with the underlying microscale organization of the cortex. Here, we further examine this link in the human brain cortex by using the ultrahigh-resolution BigBrain dataset; 11,660 BigBrain profiles of laminar cell structure were extracted from the BigBrain data and mapped to the MRI based Desikan-Killiany atlas used for macroscale connectome reconstruction. Macroscale brain connectivity was reconstructed based on the diffusion-weighted imaging dataset from the Human Connectome Project and cross-correlated to the similarity of laminar profiles. We showed that the BigBrain profile similarity between interconnected cortical regions was significantly higher than those between nonconnected regions. The pattern of BigBrain profile similarity across the entire cortex was also found to be strongly correlated with the pattern of cortico-cortical connectivity at the macroscale. Our findings suggest that cortical regions with higher similarity in the laminar cytoarchitectonic patterns have a higher chance of being connected, extending the evidence for the linkage between macroscale connectome organizati...Continue Reading

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Citations

May 11, 2019·PLoS Biology·Miguel Ángel García-Cabezas, Basilis Zikopoulos
Nov 7, 2019·Scientific Reports·Jiahe ZhangLisa Feldman Barrett
Feb 11, 2019·Brain Structure & Function·Miguel Ángel García-CabezasHelen Barbas
Dec 18, 2020·ELife·Golia ShafieiBratislav Misic
Feb 25, 2021·Cerebral Cortex·Roman BauerMarcus Kaiser
Mar 17, 2021·Cerebral Cortex·Ruth Benavides-PiccioneJavier DeFelipe
Jul 20, 2019·Biological Psychiatry·Martijn P van den HeuvelRené S Kahn
Apr 30, 2021·Nature Reviews. Neuroscience·Ursula A TooleyAllyson P Mackey
Jul 24, 2021·Cerebral Cortex Communications·Shai BermanAviv A Mezer

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Software Mentioned

FNIRT
FreeSurfer fsaverage
FLIRT
BigBrain
FreeSurfer

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