Multiscale model of fatigue of collagen gels

Biomechanics and Modeling in Mechanobiology
Rohit Y DhumeVictor H Barocas

Abstract

Fatigue as a mode of failure becomes increasingly relevant with age in tissues that experience repeated fluctuations in loading. While there has been a growing focus on the mechanics of networks of collagen fibers, which are recognized as the predominant mechanical components of soft tissues, the network's fatigue behavior has received less attention. Specifically, it must be asked (1) how the fatigue of networks differs from that of its component fibers, and (2) whether this difference in fatigue behaviors is affected by changes in the network's architecture. In the present study, we simulated cyclic uniaxial loading of Voronoi networks to model fatigue experiments performed on reconstituted collagen gels. Collagen gels were cast into dog-bone shape molds and were tested on a uniaxial machine under a tension-tension cyclic loading protocol. Simulations were performed on networks modeled as trusses of, on average, 600 nonlinear elastic fibers connected at freely rotating pin-joints. We also simulated fatigue failure of Delaunay, and Erdős-Rényi networks, in addition to Voronoi networks, to compare fatigue behavior among different architectures. The uneven distribution of stresses within the fibers of the unstructured networks r...Continue Reading

References

Feb 1, 1978·Annals of the Rheumatic Diseases·B WeightmanE A Jenkins
Feb 9, 1996·Cell·T J Mitchison, L P Cramer
Aug 1, 1997·Journal of Biomechanics·H Schechtman, D L Bader
Mar 12, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M A Freeman
May 27, 2004·Journal of Biomedical Materials Research. Part a·Wei SunMichael Scott
Apr 15, 2005·Journal of Applied Physiology·Béla SukiEdward P Ingenito
Mar 10, 2006·Journal of Biomechanical Engineering·Preethi L Chandran, Victor H Barocas
Aug 26, 2006·Biomechanics and Modeling in Mechanobiology·Raffaella De Vita, William S Slaughter
Jul 28, 2007·Journal of Biomechanical Engineering·Triantafyllos Stylianopoulos, Victor H Barocas
Oct 6, 2007·Advanced Drug Delivery Reviews·Catherine P BarnesGary L Bowlin
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Edward A SanderVictor H Barocas
Jun 18, 2011·Advanced Materials·Susan NachtrabGerd E Schröder-Turk
Jul 31, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Spencer P Lake, Victor H Barocas
Sep 5, 2012·Biomechanics and Modeling in Mechanobiology·Caitlin Martin, Wei Sun
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A Shahsavari, R C Picu
Mar 9, 2013·Acta Biomaterialia·C T KohM L Oyen
Jul 25, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Samuel P VeresJ Michael Lee
Oct 5, 2013·Biomechanics and Modeling in Mechanobiology·Caitlin Martin, Wei Sun
Dec 9, 2015·Journal of the Mechanics and Physics of Solids·Ehsan BanCatalin R Picu
Jul 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrew DittmoreKeir C Neuman
Aug 23, 2016·Journal of Biomechanical Engineering·Maziar AghvamiEdward A Sander
Nov 29, 2016·Journal of Biomechanical Engineering·Colleen M WitzenburgVictor H Barocas
Feb 28, 2017·Journal of Biomechanical Engineering·Ehsan BanCatalin R Picu
Mar 20, 2018·Acta Biomaterialia·Kevin LinkaMikhail Itskov

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Citations

May 30, 2019·Journal of Biomechanical Engineering·Christopher E KorenczukWilliam J Richardson
Aug 31, 2020·Biomedical Engineering Letters·Wenguang Li
Apr 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Federica BurlaGijsje H Koenderink
Oct 20, 2019·Computer Methods and Programs in Biomedicine·Javier Ortún-TerrazasAmaya Pérez Del Palomar

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