Multiscale modeling of cardiac cellular energetics

Annals of the New York Academy of Sciences
J B BassingthwaighteHong Qian

Abstract

Multiscale modeling is essential to integrating knowledge of human physiology starting from genomics, molecular biology, and the environment through the levels of cells, tissues, and organs all the way to integrated systems behavior. The lowest levels concern biophysical and biochemical events. The higher levels of organization in tissues, organs, and organism are complex, representing the dynamically varying behavior of billions of cells interacting together. Models integrating cellular events into tissue and organ behavior are forced to resort to simplifications to minimize computational complexity, thus reducing the model's ability to respond correctly to dynamic changes in external conditions. Adjustments at protein and gene regulatory levels shortchange the simplified higher-level representations. Our cell primitive is composed of a set of subcellular modules, each defining an intracellular function (action potential, tricarboxylic acid cycle, oxidative phosphorylation, glycolysis, calcium cycling, contraction, etc.), composing what we call the "eternal cell," which assumes that there is neither proteolysis nor protein synthesis. Within the modules are elements describing each particular component (i.e., enzymatic reaction...Continue Reading

References

Sep 9, 2011·PloS One·David O HollandJeffrey J Saucerman
Aug 22, 2014·BioMed Research International·Filippo CastiglioneSanto Motta
Mar 29, 2007·Annals of the New York Academy of Sciences·Samuel Sideman
Mar 21, 2007·Immunological Reviews·Denise E KirschnerJennifer J Linderman
Apr 8, 2009·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Amina A QutubAleksander S Popel
Jun 13, 2006·Journal of Molecular and Cellular Cardiology·Marcus C SchaubMichael Zaugg
Jun 28, 2011·Progress in Biophysics and Molecular Biology·Zhilin QuMelissa Nivala
Dec 17, 2014·Progress in Biophysics and Molecular Biology·Hieu T NimNadia A Rosenthal
Feb 21, 2014·F1000Research·Erik ButterworthJ B Bassingthwaighte
Mar 23, 2011·Cellular and Molecular Bioengineering·V A Shiva Ayyadurai, C Forbes Dewey
Mar 27, 2015·Briefings in Bioinformatics·Antonio CappuccioFilippo Castiglione

Citations

Aug 1, 1977·Archives of Biochemistry and Biophysics·D F WilsonA Holian
Oct 7, 1979·Journal of Theoretical Biology·J B ChapmanE A Johnson
Oct 1, 1978·The Journal of General Physiology·R E SaffordJ B Bassingthwaighte
Jun 1, 1977·The Journal of Physiology·G W Beeler, H Reuter
Mar 1, 1976·Annals of Biomedical Engineering·E N LightfootE F Grabowski
Jan 1, 1992·Annals of Biomedical Engineering·J B BassingthwaighteC Y Wang
Feb 1, 1992·The American Journal of Physiology·K KrollJ B Bassingthwaighte
Apr 1, 1992·IEEE Transactions on Bio-medical Engineering·P H VeltinkA el-Bialy
Apr 1, 1991·The Journal of Membrane Biology·M M Wu, M M Civan
Oct 1, 1991·IEEE Transactions on Bio-medical Engineering·N LanH J Chizeck
Dec 1, 1991·IEEE Transactions on Bio-medical Engineering·N LanH J Chizeck
Dec 1, 1991·IEEE Transactions on Bio-medical Engineering·H J ChizeckP E Crago
May 1, 1991·IEEE Transactions on Bio-medical Engineering·T L ChiaH J Chizeck
Jul 1, 1991·IEEE Transactions on Bio-medical Engineering·J J Abbas, H J Chizeck
Sep 1, 1991·The American Journal of Physiology·M W GormanH V Sparks
Jan 1, 1991·IEEE Transactions on Bio-medical Engineering·P E CragoH J Chizeck
Mar 1, 1991·IEEE Transactions on Bio-medical Engineering·W D TimmonsP G Katona
Jun 24, 1989·Molecular and Cellular Biochemistry·J B BassingthwaighteJ F Glatz
Jul 1, 1989·The American Journal of Physiology·R D WanglerH V Sparks
Sep 1, 1989·Circulation Research·J B BassingthwaighteS A Roger
Oct 1, 1989·Circulation Research·J B BassingthwaighteI S Chan
Jan 1, 1988·Pediatric Neuroscience·H L RekateW Ko
Jul 1, 1988·IEEE Transactions on Bio-medical Engineering·H J ChizeckL S Kofman
Jan 1, 1988·Pediatric Neuroscience·H L RekateW Ko
Jan 1, 1986·The American Journal of Physiology·J KuikkaJ B Bassingthwaighte
Mar 1, 1986·The American Journal of Physiology·M W GormanH V Sparks
Jan 1, 1986·Annual Review of Physiology·J B Bassingthwaighte, H V Sparks
Feb 1, 1987·IEEE Transactions on Bio-medical Engineering·L A BernotasH J Chizeck
Aug 1, 1987·IEEE Transactions on Bio-medical Engineering·G I VossH J Chizeck
Oct 1, 1987·IEEE Transactions on Bio-medical Engineering·D K Peterson, H J Chizeck
Sep 1, 1986·IEEE Transactions on Bio-medical Engineering·L A BernotasH J Chizeck
Aug 1, 1985·Circulation Research·R B KingL B Rowell
Sep 1, 1985·IEEE Transactions on Bio-medical Engineering·G F WilhereH J Chizeck
Jan 1, 1985·Annals of Biomedical Engineering·K S SternP G Katona
Jan 1, 1972·Annual Review of Physiology·A C GuytonH J Granger
Mar 1, 1974·Microvascular Research·J B BassingthwaighteR B Harvey
Sep 1, 1974·Circulation Research·J B Bassingthwaighte
Sep 1, 1984·Microvascular Research·J B BassingthwaighteT J Knopp
Nov 1, 1995·IEEE Transactions on Bio-medical Engineering·J J Abbas, H J Chizeck
Dec 1, 1995·Circulation Research·J B Bassingthwaighte, D A Beard
Mar 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·N WilkeA E Stillman
Feb 1, 1995·IEEE Transactions on Bio-medical Engineering·G ShueH J Chizeck
Aug 1, 1994·The American Journal of Physiology·J H CaldwellJ B Bassingthwaighte
Jan 1, 1994·Medicine and Science in Sports and Exercise·D F Wilson
Dec 1, 1993·The American Journal of Physiology·R B KingJ B Bassingthwaighte

Related Concepts

In Silico
Calcium [EPC]
Calcium
Exercise, Isometric
Acclimatization
Energy Metabolism
Protoplasm
Action Potentials
Contraction (Finding)
Myocardium

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Experimental Physiology
Edmund J CrampinMerryn Tawhai
Annals of the New York Academy of Sciences
Andrew D McCulloch, Giovanni Paternostro
Physical Chemistry Chemical Physics : PCCP
Teemu MurtolaMikko Karttunen
Journal of the Royal Society, Interface
Peter V Coveney, Philip W Fowler
© 2020 Meta ULC. All rights reserved