Multiscale modeling is essential to integrating knowledge of human physiology starting from genomics, molecular biology, and the environment through the levels of cells, tissues, and organs all the way to integrated systems behavior. The lowest levels concern biophysical and biochemical events. The higher levels of organization in tissues, organs, and organism are complex, representing the dynamically varying behavior of billions of cells interacting together. Models integrating cellular events into tissue and organ behavior are forced to resort to simplifications to minimize computational complexity, thus reducing the model's ability to respond correctly to dynamic changes in external conditions. Adjustments at protein and gene regulatory levels shortchange the simplified higher-level representations. Our cell primitive is composed of a set of subcellular modules, each defining an intracellular function (action potential, tricarboxylic acid cycle, oxidative phosphorylation, glycolysis, calcium cycling, contraction, etc.), composing what we call the "eternal cell," which assumes that there is neither proteolysis nor protein synthesis. Within the modules are elements describing each particular component (i.e., enzymatic reaction...Continue Reading
Systems approaches in integrative cardiac biology: illustrations from cardiac heterocellular signalling studies
CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models
Control of mitochondrial respiration: a quantitative evaluation of the roles of cytochrome c and oxygen
The effect of Mg2+ and chelating agents on intermediary steps of the reaction ofNa+,K+-activated ATPase
Relationship between internal calcium and outward current in mammalian ventricular muscle; a mechanism for the control of the action potential duration?
Computationally efficient algorithms for convection-permeation-diffusion models for blood-tissue exchange
Feedback control of electrically stimulated muscle using simultaneous pulse width and stimulus period modulation
Recursive parameter identification of constrained systems: an application to electrically stimulated muscle
Feedback control of coronal plane hip angle in paraplegic subjects using functional neuromuscular stimulation
Adaptive multivariable drug delivery: control of arterial pressure and cardiac output in anesthetized dogs
Design and evaluation of a digital closed-loop controller for the regulation of muscle force by recruitment modulation
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
Calcium & Bioenergetics
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.