Multiscale modeling of layer formation in epidermis

PLoS Computational Biology
Huijing DuQ Nie

Abstract

The mammalian skin epidermis is a stratified epithelium composed of multiple layers of epithelial cells that exist in appropriate sizes and proportions, and with distinct boundaries separating each other. How the epidermis develops from a single layer of committed precursor cells to form a complex multilayered structure of multiple cell types remains elusive. Here, we construct stochastic, three-dimensional, and multiscale models consisting of a lineage of multiple cell types to study the control of epidermal development. Symmetric and asymmetric cell divisions, stochastic cell fate transitions within the lineage, extracellular morphogens, cell-to-cell adhesion forces, and cell signaling are included in model. A GPU algorithm was developed and implemented to accelerate the simulations. These simulations show that a balance between cell proliferation and differentiation during lineage progression is crucial for the development and maintenance of the epidermal tissue. We also find that selective intercellular adhesion is critical to sharpening the boundary between layers and to the formation of a highly ordered structure. The long-range action of a morphogen provides additional feedback regulations, enhancing the robustness of ov...Continue Reading

References

Jun 1, 1985·The Journal of Investigative Dermatology·G K MenonP M Elias
Apr 25, 2002·Nature Reviews. Genetics·Elaine Fuchs, Srikala Raghavan
Nov 26, 2002·The Journal of Investigative Dermatology·Peter M EliasKenneth R Feingold
May 11, 2007·Annual Review of Cell and Developmental Biology·Maranke I Koster, Dennis R Roop
Jan 23, 2008·The Journal of Cell Biology·Elaine Fuchs
Jan 27, 2009·PLoS Biology·Arthur D LanderAnne L Calof
Feb 12, 2009·Nature Reviews. Molecular Cell Biology·Cédric Blanpain, Elaine Fuchs
Mar 19, 2009·Mathematical Biosciences and Engineering : MBE·Wing-Cheong LoQing Nie
Nov 18, 2010·Biophysical Journal·Ching-Shan ChouQing Nie
Feb 19, 2011·Nature·Scott E WilliamsElaine Fuchs
Sep 18, 2012·Seminars in Cell & Developmental Biology·Amit Roshan, Philip H Jones
Nov 26, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Shaowen Hu, Francis A Cucinotta
Jan 9, 2015·Journal of the Royal Society, Interface·Hong ZhangJin Yang
Jan 24, 2017·PLoS Computational Biology·William R HolmesQing Nie
Feb 14, 2017·PLoS Computational Biology·James M OsborneDavid J Gavaghan

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Citations

Jan 31, 2020·BMC Bioinformatics·Satya N V ArjunanKoichi Takahashi
May 10, 2021·The Journal of Investigative Dermatology·Raneem TayemMonique Aumailley
Jun 14, 2021·Journal of Theoretical Biology·Claire MillerJames M Osborne

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Methods Mentioned

BETA
transgenic

Software Mentioned

GSEA
Ovol
OpenCL
Affymetrix GeneChip Analysis Suite

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