Multiscale modeling of virus replication and spread

FEBS Letters
Peter KumbergerFrederik Graw

Abstract

Replication and spread of human viruses is based on the simultaneous exploitation of many different host functions, bridging multiple scales in space and time. Mathematical modeling is essential to obtain a systems-level understanding of how human viruses manage to proceed through their life cycles. Here, we review corresponding advances for viral systems of large medical relevance, such as human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV). We will outline how the combination of mathematical models and experimental data has advanced our quantitative knowledge about various processes of these pathogens, and how novel quantitative approaches promise to fill remaining gaps.

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Citations

Dec 21, 2016·PloS One·Gennady BocharovVitaly Volpert
Aug 30, 2017·Journal of Biological Dynamics·Winston Garira
Dec 25, 2019·Physical Review. E·Felix FreyUlrich S Schwarz
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Jul 14, 2016·FEBS Letters·Oliver T Fackler, Hans-Georg Kräusslich
Jan 18, 2021·Biochemical and Biophysical Research Communications·Wei-Chung ChiouCheng Huang
Dec 6, 2020·Science Advances·Iván Andreu-MorenoRafael Sanjuán
Oct 14, 2021·Cell Reports·Soheil Rastgou TalemiThomas Höfer

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