PMID: 8945034Nov 1, 1996Paper

Multisite pacing for end-stage heart failure: early experience

Pacing and Clinical Electrophysiology : PACE
S CazeauJ Mugica

Abstract

Our objective was to improve hemodynamics by synchronous right and left site ventricular pacing in patients with severe congestive heart failure (CHF). Previous studies reported a benefit of dual chamber pacing with a short AV delay in patients with severe CHF. Other works, however, show contradictory results. Deleterious effects due to a desynchronization of right (RV) and left ventricular (LV) contractions have been suggested. This study included eight subjects with widened QRS and end-stage heart failure despite maximal medical therapy, who refused, or were not eligible to undergo heart transplantation, Each patient underwent a baseline, invasive hemodynamic evaluation with insertion of three temporary leads to allow different pacing configurations, including RV apex and outflow tract pacing, and biventricular pacing between the RV outflow tract and LV and RV apex and LV. According to the results of this baseline study, the configuration of preexistent pacemakers was modified or new systems were implanted to allow biventricular pacing, which, in patients with sinus rhythm, was atrial triggered. Biventricular pacing increased the mean cardiac index (CI) by 25% (from a baseline of 1.83 +/- 0.30 L/min per m2, P < 0.006), decrea...Continue Reading

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Citations

Apr 13, 2005·Herzschrittmachertherapie & Elektrophysiologie·J VogtD Horstkotte
Apr 13, 2005·Herzschrittmachertherapie & Elektrophysiologie·C Stellbrink
Mar 12, 2008·Herzschrittmachertherapie & Elektrophysiologie·G Fröhlig, M Kindermann
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Sep 29, 2005·Clinical and Experimental Nephrology·Tetsuro KusabaSusumu Sasaki
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Jul 23, 2005·Current Heart Failure Reports·Andrew C Wickliffe, Angel R Leon
Sep 6, 2005·Current Treatment Options in Cardiovascular Medicine·Edward K Rhee
Mar 5, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Alan D WaggonerVictor G Davila-Roman
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Nov 21, 2000·The American Journal of Cardiology·H PürerfellnerUNKNOWN European EASYTRAK Registry
Nov 21, 2000·The American Journal of Cardiology·C ButterUNKNOWN Pacing Therapies in Congestive Heart Failure II Study Group
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Jan 15, 2002·Journal of the American College of Cardiology·Christophe Leclercq, David A Kass
Mar 1, 2002·Journal of the American College of Cardiology·Volker Kühlkamp, UNKNOWN InSync 7272 ICD World Wide Investigators
Jun 27, 2002·Journal of the American College of Cardiology·Angelo AuricchioUNKNOWN Pacing Therapies in Congestive Heart Failure (PATH-CHF) Study Group
Feb 25, 2003·Journal of the American College of Cardiology·Chetan VarmaUNKNOWN Multisite Stimulation in Cardiomyopathy (MUSTIC) Study Group
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Jul 21, 2006·The New England Journal of Medicine·John A Jarcho
Mar 15, 2012·European Heart Journal·Eugene Braunwald
Jan 24, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Máximo Rivero-Ayerza, Beat Schaer
Jan 17, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alf Inge LarsenDennis W T Nilsen
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