Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family

Molecular Biology and Evolution
Kohtaro TanakaÉlio Sucena

Abstract

Gene families often consist of members with diverse expression domains reflecting their functions in a wide variety of tissues. However, how the expression of individual members, and thus their tissue-specific functions, diversified during the course of gene family expansion is not well understood. In this study, we approached this question through the analysis of the duplication history and transcriptional evolution of a rapidly expanding subfamily of insect Ly6 genes. We analyzed different insect genomes and identified seven Ly6 genes that have originated from a single ancestor through sequential duplication within the higher Diptera. We then determined how the original embryonic expression pattern of the founding gene diversified by characterizing its tissue-specific expression in the beetle Tribolium castaneum, the butterfly Bicyclus anynana, and the mosquito Anopheles stephensi and those of its duplicates in three higher dipteran species, representing various stages of the duplication history (Megaselia abdita, Ceratitis capitata, and Drosophila melanogaster). Our results revealed that frequent neofunctionalization episodes contributed to the increased expression breadth of this subfamily and that these events occurred aft...Continue Reading

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Citations

Jan 12, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Markus Friedrich, Jeffery W Jones
Sep 30, 2017·Molecular Biology and Evolution·Luís Baudouin-GonzalezKohtaro Tanaka
Sep 7, 2017·Evolution; International Journal of Organic Evolution·Linh M Chau, Michael A D Goodisman
Jun 15, 2019·International Journal of Molecular Sciences·Julie Maja LethMichael Ploug

Methods Mentioned

BETA
protein-trap
protein
RNA-seq
transgenic

Related Concepts

Metazoa
Embryonic Structures, Nonmammalian
Genes, Reiterated
Insecta
Tissue Specificity
Phylogeny
Genes, Insect
Evolution, Molecular
Gene Duplication
MRNA Differential Display

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