Multistimuli-responsive drug vehicles based on gold nanoflowers for chemophotothermal synergistic cancer therapy

Nanomedicine
Tian YinDawei Gao

Abstract

To design and synthesize a novel multistimuli-responsive drug vehicle based on gold nanoflowers (AuNFs) for chemophotothermal synergistic cancer therapy. Multistimuli-responsive drug-delivery system based on doxorubicin (DOX)/polydopamine (PDA)-functionalized AuNFs (Lan-AuNFs@PDA/DOX) was prepared. The structural characteristics, photothermal properties and stimuli-responsive drug release properties of Lan-AuNFs@PDA/DOX were evaluated. Antitumor studies in vivo and in vitro were performed. Lan-AuNFs@PDA/DOX exhibited uniform morphology, excellent biocompatibility and photothermal conversion efficiency, which could also respond to stimulus including near infrared light and pH to trigger on demand drug release. The excellent synergistic therapeutic efficacy was confirmed both in vitro and in vivo. Lan-AuNFs@PDA/DOX would be a promising drug carrier, endowing a great potential for multistimuli-responsive chemophotothermal synergistic cancer therapy.

References

Jul 31, 2002·The Lancet Oncology·P WustP M Schlag
Jul 15, 2004·Journal of the American Chemical Society·Tapan K Sau, Catherine J Murphy
Feb 7, 2007·Nano Letters·Feng HaoPeter Nordlander
Oct 6, 2007·Science·Anthony K Cheetham, C N R Rao
Oct 12, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Anjali PanditMaïté Paternostre
Oct 20, 2007·Science·Haeshin LeePhillip B Messersmith
Nov 13, 2007·Biophysical Journal·Céline ValéryMaité Paternostre
May 10, 2008·Journal of the American Chemical Society·Feng-Ru FanZhong-Qun Tian
Nov 7, 2009·Journal of the American Chemical Society·Steven D Perrault, Warren C W Chan
Dec 24, 2010·Critical Reviews in Biomedical Engineering·Wei RaoJing Liu
May 11, 2011·Nano Letters·Colin M HesselBrian A Korgel
Oct 26, 2011·Nanoscale·Martin E LyngeBrigitte Städler
Apr 6, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Daniel R DreyerChristopher W Bielawski
Jan 8, 2013·Expert Opinion on Drug Delivery·Jonathan P May, Shyh-Dar Li
Sep 21, 2013·Advanced Materials·Zhenjiang ZhangChunying Chen
Dec 7, 2013·Therapeutic Delivery·Xi HeChen Jiang
Jul 25, 2014·Chemical Communications : Chem Comm·Jing YuYanglong Hou
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Apr 3, 2015·Macromolecular Rapid Communications·Yanqin GaoChang-Ming Dong
Aug 11, 2015·Journal of the American Chemical Society·Wenxin NiuXianmao Lu
Jun 29, 2016·ACS Applied Materials & Interfaces·Xiaoxiao WangZhifei Wang
Aug 27, 2016·ACS Applied Materials & Interfaces·Shaowei WangSailing He
Dec 7, 2017·Biochemical Pharmacology·Stefanie DichtlGünter Weiss

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Citations

Feb 18, 2020·Nanomedicine·Dana M SamhadanehUrsula Stochaj
Jun 9, 2021·Chemical Society Reviews·Peng YangYiwen Li
Sep 9, 2019·ACS Biomaterials Science & Engineering·Xuwu ZhangDawei Gao

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Methods Mentioned

BETA
surface plasmon resonance
fluorescence microscopy
X-ray
Fluorescence
surface plasmonic resonance

Software Mentioned

SPSS

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