Multisystem atrophy made worse by lithium treatment in a hospice patient: a case report

The American Journal of Hospice & Palliative Care
Ellen Babinsky, Richard S Levene

Abstract

Multisystem atrophy is a neurologic condition defined as an adult-onset, progressive, neurodegenerative disease of unknown etiology. It carries a multisystem clinical course, including autonomic, urogenital, cerebellar, and parkinsonian features. Lithium toxicity, classically manifesting as increased thirst, polyuria, gastric distress, weight gain, tremor, fatigue, and mild cognitive impairment, can present in a similar manner.(1) We would like to present a patient diagnosed with progressive neurologic features typical of multisystem atrophy that also had bipolar disorder and had been taking lithium for many years. Despite normal lithium levels, it appeared as though a subclinical lithium toxicity was manifesting in the patient, and once lithium was discontinued, the patient was discharged from hospice with significant improvement in his presenting symptoms.

References

Dec 30, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S GilmanG Wenning
Jan 23, 1999·Journal of the Autonomic Nervous System·S GilmanG K Wenning
May 9, 2007·Archives of General Psychiatry·Kathleen R MerikangasRonald C Kessler
Nov 17, 2009·Lancet Neurology·Nadia StefanovaGregor Karl Wenning
Jul 2, 2010·Psychiatric Services : a Journal of the American Psychiatric Association·Elizabeth E PiattChristian Ritter

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Citations

Dec 1, 2017·Clinical Drug Investigation·Meng SunKenneth I Shulman

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