Multisystem evaluations of the long-term effects of tibolone on postmenopausal monkeys

Maturitas
Thomas B ClarksonA G H Ederveen

Abstract

This long-term study (2 years) was designed to compare the effects of tibolone (LoTib at 0.05 mg/kg and HiTib at 0.2 mg/kg) with those of conjugated equine oestrogens (CEE) alone (0.042 mg/kg) and CEE continuously combined with medroxyprogesterone acetate (MPA) (0.167 mg/kg) on coronary artery atherosclerosis, bone, mammary gland and uterus in ovariectomised cynomolgus monkeys fed a moderately atherogenic diet. Despite reductions in plasma concentrations of high density lipoprotein cholesterol in tibolone-treated monkeys, there was no exacerbation of coronary artery atherosclerosis. Tibolone was equivalent to, or slightly better than, CEE and CEE + MPA in protecting against postmenopausal bone loss and loss of bone strength. Tibolone also resulted in less stimulation of breast and endometrial tissue compared with CEE and CEE + MPA. In conclusion, the results suggest that tibolone is a cardiovascular-safe treatment that is effective for the prevention of osteoporosis and that may have advantages over CEE or CEE + MPA with regard to endometrial and breast safety.

Citations

Jul 1, 2006·Women's Health·May Wahab, Farook Al-Azzawi
Dec 17, 2011·Women's Health·Kate Maclaran, John C Stevenson
Jul 1, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicoletta BigliaRossella E Nappi
Sep 29, 2011·Climacteric : the Journal of the International Menopause Society·H J Kloosterboer
Nov 23, 2006·The Journal of Steroid Biochemistry and Molecular Biology·H A M Verheul, H J Kloosterboer
Jul 7, 2007·Cardiovascular Drug Reviews·Roxana Campisi, Fernando D Marengo
Sep 11, 2019·Medicina·Paola VillaGiovanni Scambia
Apr 11, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·H A M VerheulH J Kloosterboer

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