Multisystem inflammatory syndrome in children with COVID-19.

The American Journal of Emergency Medicine
Michael GottliebBrit Long

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a dangerous pediatric complication of COVID-19. The purpose of this review article is to provide a summary of the diagnosis and management of MIS-C with a focus on management in the acute care setting. MIS-C is an inflammatory syndrome which can affect nearly any organ system. The most common symptoms are fever and gastrointestinal symptoms, though neurologic and dermatologic findings are also well-described. The diagnosis includes a combination of clinical and laboratory testing. Patients with MIS-C will often have elevated inflammatory markers and may have an abnormal electrocardiogram or echocardiogram. Initial treatment involves resuscitation with careful assessment for cardiac versus vasodilatory shock using point-of-care ultrasound. Treatment should include intravenous immunoglobulin, anticoagulation, and consideration of corticosteroids. Interleukin-1 and/or interleukin-6 blockade may be considered for refractory cases. Aspirin is recommended if there is thrombocytosis or Kawasaki disease-like features on echocardiogram. Patients will generally require admission to an intensive care unit. MIS-C is a condition associated with morbidity and mortality that is increasi...Continue Reading

References

Sep 2, 2003·Pediatrics·Robert C HolmanLawrence B Schonberger
Dec 3, 2004·Pediatrics·Jane W NewburgerUNKNOWN Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American H
Feb 25, 2009·Pediatrics·Wen-Chan HuangUNKNOWN Kawasaki Disease Research Group
Jan 28, 2010·The Pediatric Infectious Disease Journal·Robert C HolmanLawrence B Schonberger
Sep 21, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Christina RonaiKevin G Friedman
Nov 8, 2016·The Journal of Pediatrics·Mei-Hwan WuSan-Kuei Huang
Jan 26, 2018·The Journal of Emergency Medicine·Michael GottliebAlex Koyfman
Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
May 11, 2020·Lancet·Shelley RiphagenParaskevi Theocharis
May 15, 2020·The Journal of Pediatrics·Roberta L DeBiasiDavid Wessel
May 20, 2020·The American Journal of Emergency Medicine·Rachel BridwellMichael Gottlieb
May 29, 2020·Journal of the Pediatric Infectious Diseases Society·Kathleen ChiotosAudrey R Odom John
Jun 9, 2020·JAMA : the Journal of the American Medical Association·Eva W CheungJoshua D Milner
Jun 9, 2020·JAMA : the Journal of the American Medical Association·Elizabeth WhittakerUNKNOWN PIMS-TS Study Group and EUCLIDS and PERFORM Consortia
Jul 1, 2020·The New England Journal of Medicine·Elizabeth M DufortUNKNOWN New York State and Centers for Disease Control and Prevention Multisystem Inflammatory Syndrome in Children Investigation Te
Jul 1, 2020·The New England Journal of Medicine·Leora R FeldsteinUNKNOWN CDC COVID-19 Response Team
Jul 24, 2020·The Journal of Clinical Investigation·Pui Y LeeMary Beth F Son
Aug 7, 2020·AJR. American Journal of Roentgenology·Einat BlumfieldMark C Liszewski
Aug 14, 2020·The American Journal of Case Reports·Sabrina M HeidemannAshok P Sarnaik
Aug 14, 2020·MMWR. Morbidity and Mortality Weekly Report·Shana Godfred-CatoUNKNOWN California MIS-C Response Team
Aug 24, 2020·The Lancet Child & Adolescent Health·Marisa DolhnikoffElia Garcia Caldini
Aug 25, 2020·The Lancet Child & Adolescent Health·Kate WebbUNKNOWN Cape Town MISC-Team
Sep 2, 2020·The Journal of Clinical Investigation·Anne H RowleyMoshe Arditi
Sep 6, 2020·Journal of the American College of Cardiology·Daisuke MatsubaraAnirban Banerjee
Sep 15, 2020·EClinicalMedicine·Mubbasheer AhmedAlvaro Moreira
Sep 15, 2020·The Pediatric Infectious Disease Journal·Ashlesha KaushikShikha Verma
Sep 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mary Hongying ChengIvet Bahar
Oct 11, 2020·The American Journal of Emergency Medicine·Amy M DeLarocheRonald P Ruffing
Oct 31, 2020·Pediatric Emergency Care·Andrew F MillerJason A Levy
Nov 10, 2020·Circulation·Israel ValverdeUNKNOWN on behalf the AEPC COVID-19 rapid response team
Nov 26, 2020·Pediatrics·Carles Bautista-RodriguezAlain Fraisse
Dec 11, 2020·The Pediatric Infectious Disease Journal·Kavita MorpariaTej Phatak

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