PMID: 9537561Apr 16, 1998Paper

Multisystem organ failure and capillary leak syndrome in severe necrotizing enterocolitis of very low birth weight infants

Journal of Pediatric Surgery
J SonntagM Obladen

Abstract

Classification systems for necrotizing enterocolitis (NEC) in preterm infants have been developed to define severity grades relevant for treatment and prognosis. Multisystem organ failure (MSOF) and capillary leak syndrome (CLS) also have prognostic value in these patients. The aim of this retrospective study was to investigate the incidence and predictive value of MSOF and CLS according to the classification criteria. The records of 1,022 very low birth weight infants admitted from 1982 to 1996 were reviewed for diagnosis of NEC stage IIA or higher (classification of Walsh and Kliegman). Among those patients (n = 50) the incidence of MSOF and CLS was determined, separately for surgical or conservative treatment. Twelve patients were assigned to stage II, 22 to stage IIIa, and 16 to stage IIIb; 31 infants underwent operation. Mortality rate was not influenced by the grade. In eight patients only gastrointestinal symptoms were found, whereas in 23 patients, up to three organ systems and in 19 patients, four or more organ systems were affected. Mortality depended on the number of involved organ systems. CLS occurred postoperatively in 10 of the 31 infants; eight of them died. The prognostic values of MSOF and CLS are higher than ...Continue Reading

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Citations

Oct 8, 2005·Pediatric Surgery International·Renu SharmaMonica Sharma
Feb 18, 2004·Journal of Pediatric Surgery·Renu SharmaPeter Wludyka
Jul 4, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·George Simbruner
Aug 24, 2006·Journal of Paediatrics and Child Health·Amuchou S SoraishamReginald S Sauve
Oct 27, 2009·Pediatric Surgery International·Augusto ZaniSimon Eaton
May 12, 2000·Seminars in Pediatric Surgery·J C Chandler, A Hebra
Aug 8, 2015·Clinics in Perinatology·Akhil Maheshwari
Oct 25, 2013·Expert Opinion on Biological Therapy·Simon EatonPaolo De Coppi
Sep 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rhonnie SongAkhil Maheshwari
Jan 21, 2015·La Revue de médecine interne·L DuronL Arnaud
Aug 4, 2018·Pediatric Research·Alan M GrovesUNKNOWN European Special Interest Group ‘Neonatologist Performed Echocardiography’ (NPE)
Oct 21, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Pamela J Kling, John J Hutter
Feb 12, 2019·F1000Research·Mashriq AlganabiAgostino Pierro

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