Multisystemic abscesses in African green monkeys (Chlorocebus aethiops) with invasive Klebsiella pneumoniae--identification of the hypermucoviscosity phenotype

Veterinary Pathology
N A TwenhafelK E Steele

Abstract

Invasive Klebsiella pneumoniae is an emerging disease of humans characterized by abscesses in the liver or other sites involving bacteria with the unique hypermucoviscosity phenotype. Over several months, 7 African green monkeys in our research colony developed abscess formation in multiple locations and succumbed to disease. K. pneumoniae was identified by bacterial culture in 6 monkeys and immunohistochemistry in 1 additional monkey. All monkeys had been housed in, or had contact with monkeys housed in, 1 animal room in our facility. All affected monkeys had 1 or more abscesses, most notably in the abdomen, but also affecting the lungs, cerebellum, and skin. Abdominal abscesses and associated adhesions entrapped loops of bowel, forming palpable masses. Abdominal masses were located at the root of the mesentery, the ileocecocolic junction, or the pelvic inlet. In 1 case, culture, serotyping, and polymerase chain reaction (PCR) analysis of the bacterial isolate identified K. pneumoniae expressing the hypermucoviscosity phenotype and capsular serotype K2 and determined that the K. pneumonia was genetically rmpA(+)/magA(-).

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Citations

Jun 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kathryn E HoltNicholas R Thomson
Jan 24, 2015·Veterinary Microbiology·Brandi L CoxEsteban Soto
Jan 9, 2019·Molecular & Cellular Proteomics : MCP·Sarah L KeaseyRobert G Ulrich
Apr 12, 2012·Journal of Psycholinguistic Research·David J Townsend
May 17, 2019·Clinical Microbiology Reviews·Thomas A Russo, Candace M Marr
Apr 1, 2019·Molecular & Cellular Proteomics : MCP·Sarah L KeaseyRobert G Ulrich
Jun 16, 2021·ILAR Journal·Chandra SaravananHsi-Yu Yen

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Methods Mentioned

BETA
PCR
dissection

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