PMID: 9539369Apr 16, 1998Paper

Multisystemic, eosinophilic, epitheliotropic disease with intestinal lymphosarcoma in a horse

Veterinary Pathology
K M La PerleE A Blomme

Abstract

Multisystemic, eosinophilic, epitheliotropic disease and intestinal lymphosarcoma were diagnosed in a Paso Fino mare that presented with anorexia and weight loss. The stomach, ileum, cecum, colon, pancreas, and lungs were infiltrated by large numbers of eosinophils forming prominent eosinophilic granulomas, as well as lymphocytes and plasma cells. Two jejunal masses composed of solid sheets of neoplastic lymphocytes were present. In contrast to the regions of inflammation, the infiltrates in these masses did not contain plasma cells, eosinophils, and eosinophilic granulomas. Immunohistochemically, the neoplastic lymphocytes expressed CD3 but not CD20 or kappa and lambda light chains, supporting a diagnosis of T-cell lymphosarcoma. Concurrent diagnoses of hypereosinophilic syndrome and lymphosarcoma in this horse and several humans suggest that the multisystemic eosinophilic and lymphoplasmacytic infiltrates were caused by the clonal proliferation of T-lymphocytes that secreted interleukin-5 triggering differentiation and activation of eosinophils.

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Citations

Feb 28, 2013·New Zealand Veterinary Journal·L BosselerS Vandenabeele
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May 24, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Larisa Pinte, Cristian Băicuș

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