Multitargeting Antibacterial Activity of a Synthesized Mn2+ Complex of Curcumin on Gram-Positive and Gram-Negative Bacterial Strains

ACS Omega
Tanmoy SahaSaurabh Das

Abstract

Curcumin is an important molecule with a plethora of pharmacological activities and therapeutic potentials. Despite its efficacy, it remained a potential drug candidate owing to hydrolytic instability and poor aqueous solubility. To overcome the limitations related to low solubility, low bioavailability, and the fact that curcumin is never present in solution as a "single unit", its complex was prepared with MnII with the idea that binding to a metal ion might help to resolve these issues. The complex was characterized by elemental and spectral analysis. The structure of the complex was determined by density functional theory calculations. The complex was stable at physiological buffer conditions, unlike curcumin. It did not have any detrimental effect on mammalian cells. There was a significant enhancement in the antibacterial activity of the complex compared to curcumin against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. It showed a strong affinity for deoxyribonucleic acid (DNA) evident from a high binding constant value with calf thymus DNA and also from the retarded electrophoretic mobility of bacterial plasmid DNA. The complex showed "superoxide dismutase-like" activity leadin...Continue Reading

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Methods Mentioned

BETA
flow cytometry
scanning electron microscopy
transmission electron microscopy
electrophoretic
electrophoresis
circular dichroism

Software Mentioned

Gauss Sum
Gaussian
CAM

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