Multivariable normal-tissue complication modeling of acute esophageal toxicity in advanced stage non-small cell lung cancer patients treated with intensity-modulated (chemo-)radiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Robin WijsmanJohan Bussink

Abstract

The majority of normal-tissue complication probability (NTCP) models for acute esophageal toxicity (AET) in advanced stage non-small cell lung cancer (AS-NSCLC) patients treated with (chemo-)radiotherapy are based on three-dimensional conformal radiotherapy (3D-CRT). Due to distinct dosimetric characteristics of intensity-modulated radiation therapy (IMRT), 3D-CRT based models need revision. We established a multivariable NTCP model for AET in 149 AS-NSCLC patients undergoing IMRT. An established model selection procedure was used to develop an NTCP model for Grade ⩾2 AET (53 patients) including clinical and esophageal dose-volume histogram parameters. The NTCP model predicted an increased risk of Grade ⩾2 AET in case of: concurrent chemoradiotherapy (CCR) [adjusted odds ratio (OR) 14.08, 95% confidence interval (CI) 4.70-42.19; p<0.001], increasing mean esophageal dose [Dmean; OR 1.12 per Gy increase, 95% CI 1.06-1.19; p<0.001], female patients (OR 3.33, 95% CI 1.36-8.17; p=0.008), and ⩾cT3 (OR 2.7, 95% CI 1.12-6.50; p=0.026). The AUC was 0.82 and the model showed good calibration. A multivariable NTCP model including CCR, Dmean, clinical tumor stage and gender predicts Grade ⩾2 AET after IMRT for AS-NSCLC. Prior to clinical i...Continue Reading

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Feb 3, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sophia C KamranDavid Craft
Jan 25, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yi PanOlfred Hansen
Mar 1, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karoline PilzEsther G C Troost
Sep 21, 2016·Best Practice & Research. Clinical Gastroenterology·Sonja AdebahrThomas B Brunner
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elisabeth J M DriessenMaryska L G Janssen-Heijnen
Dec 25, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Guillaume PeyragaOlivier Dupuis
Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Willem GrootjansJohan Bussink
Nov 10, 2018·Oral Oncology·N Patrik Brodin, Wolfgang A Tomé
Nov 7, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alexander YaneyJose G Bazan
May 1, 2021·International Journal of Molecular Sciences·Antonio Jesús Banegas-LunaHoracio Pérez-Sánchez

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