Multivariable prediction of seizure outcome one year after resective epilepsy surgery: development of a model with independent validation

Epilepsy Research
A T BergS S Spencer

Abstract

To identify predictors of seizure-outcome after epilepsy surgery and validate the findings in an independent series of patients. To use the results to develop a predictive model. Sequential patients undergoing resective surgery for medically intractable epilepsy were identified at Yale New Haven Hospital (1987-1990, group 1) and Columbia Presbyterian Hospital (1991-1994, group 2). Information about seizure outcome and predictors of outcome was obtained from medical chart review. Good seizure-outcome was defined as having been seizure-free for one year beginning with discharge from the hospital. Multiple logistic regression was used to develop a model of predictors in group 1. It was then validated in group 2. There were 133 patients in group 1 and 81 in group 2. In a multivariable analysis, independent predictors of outcome in group 1 were presence of mesial temporal sclerosis based on postsurgical pathological analysis (MTS) (relative risk (RR) = 1.47), having a known underlying etiology (RR = 1.32), and partial seizures only (RR = 1.17). In group 2, the findings for each factor were similar to those in group 1: MTS, RR = 1.49; etiology, RR = 1.32; and partial seizures, RR = 1.24. Used in combination, these three factors can i...Continue Reading

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Citations

Jan 31, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Joon Young ChoiSang Eun Kim
Dec 31, 2003·Epilepsy & Behavior : E&B·Rama MagantiBermans Iskandar
Jul 25, 2003·Magnetic Resonance Imaging·Colin P DohertyHugh Staunton
Aug 30, 2008·Epilepsia·Susanne Aull-WatschingerChristoph Baumgartner
Nov 12, 2010·Epilepsia·Sarah E BuckinghamMichael R Sperling
Nov 26, 2008·Journal of Neurosurgery·Alaa Eldin ElsharkawyAlois Ebner
Jul 10, 2003·Lancet Neurology·Susan S Spencer
Jun 23, 2012·Acta neurochirurgica·Christian-Andreas MuellerJohannes Schramm
Mar 16, 2004·Acta Neurologica Scandinavica·K StavemI A Langmoen
Mar 13, 2014·Epilepsia·Sameer A ShethEmad N Eskandar
Nov 3, 2004·Epilepsy Research·C ToniniS Wiebe
Aug 17, 2005·Epilepsy & Behavior : E&B·Jorge G BurneoRuben I Kuzniecky
Jul 15, 2015·Acta neurochirurgica·Sofia KasradzeAndro Zangaladze
May 26, 2004·Seizure : the Journal of the British Epilepsy Association·Lauro Wichert-AnaAmérico Ceiki Sakamoto
Jun 27, 2006·Seizure : the Journal of the British Epilepsy Association·Sang-Ahm LeeJung Kyo Lee
Apr 12, 2008·Seizure : the Journal of the British Epilepsy Association·F Irsel TezerSerap Saygi
Aug 2, 2016·Lancet Neurology·Nathalie JettéMark R Keezer
Jul 2, 2015·The Cochrane Database of Systematic Reviews·Siobhan WestRichard Newton
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Johanna WeissWalter Emil Haefeli
Jun 27, 2019·The Cochrane Database of Systematic Reviews·Siobhan WestRichard Newton
Jan 26, 2005·Annals of Neurology·Anne M McIntoshSamuel F Berkovic

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