Multivariate analysis of biochemical markers in synovial fluid from the shoulder joint for diagnosis of rotator cuff tears

Rheumatology International
Toshihisa OsawaKenji Takagishi

Abstract

Multivariate discriminant analysis allowed definition of cytokine, matrix metalloproteinases (MMP), and tissue inhibitors of metalloproteinases (TIMP) levels in synovial fluid (SF) of patients with rotator cuff tears and other shoulder lesions. We analyzed SF aspirated from the glenohumeral joints of 17 patients with rotator cuff tears; SF from nine patients with other shoulder lesions was used to characterize a non-rotator-cuff-tear (NRCT) group. Discriminant analysis demonstrated statistically significant differences in (1) the determination of whether rotator cuff tear patients are separable from the NRCT group using the influential functions, the most influential of which were interleukin 1-beta, MMP-2, and MMP-13, and (2) the assessment of whether full-thickness rotator cuff tears are distinguishable from partial tears using identical influential functions. The most influential function in the latter analysis was MMP-13. Both interleukin 1-beta and MMP-13 might be biochemical markers of impending rotator cuff tears.

References

Feb 15, 1984·The Biochemical Journal·D D Dean, J F Woessner
Mar 1, 1995·Journal of Shoulder and Elbow Surgery·S J Hattrup
Feb 14, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A RatcliffeB Diamond
Sep 12, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P AlstergrenS Kopp
Oct 3, 1999·The Journal of Bone and Joint Surgery. American Volume·K L JensenC A Rockwood
Oct 8, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·T TakahashiM Fukuda
Jul 6, 2000·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·M MaiottiM Coletta
Feb 24, 2001·The Journal of Bone and Joint Surgery. American Volume·R H CofieldC M Rowland
Mar 20, 2001·Lancet·G A Murrell, J R Walton
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Y YoshiharaH Fukuda

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Citations

Apr 13, 2012·Orthopedics·Jinny JacobJack Choueka
Dec 5, 2014·Arthroscopy Techniques·Lindsey S CaldwellJohn C Elfar
Oct 12, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kirsten LundgreenLars Engebretsen
May 15, 2013·Journal of Shoulder and Elbow Surgery·Erik J KramerBrian T Feeley
Jan 19, 2016·Journal of Shoulder and Elbow Surgery·Geoffrey D AbramsJeremy Sokolove
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Salma Chaudhury, Andrew J Carr
Jul 26, 2011·Journal of Shoulder and Elbow Surgery·Jonathan T NassosThay Q Lee
Mar 20, 2009·Journal of Shoulder and Elbow Surgery·Christopher S AhmadLouis U Bigliani
May 2, 2015·International Journal of Rheumatic Diseases·Koichi OkamuraKenji Takagishi
May 2, 2016·Journal of Shoulder and Elbow Surgery·Salma ChaudhuryAndrew J Carr
Jul 1, 2017·The American Journal of Sports Medicine·Jin-Ok AhnSae Hoon Kim
Aug 17, 2012·The American Journal of Sports Medicine·Catherine M RobertsonRussell F Warren
Sep 27, 2018·JBJS Reviews·Jinjin MaKathleen A Derwin
Jul 6, 2007·The Journal of Veterinary Medical Science·Masayuki NomuraKatsuhiko Arai
Jan 26, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yoichi KoikeHans K Uhthoff
Nov 22, 2018·American Journal of Physical Medicine & Rehabilitation·Nathan S HogaboomMichael L Boninger
Feb 26, 2019·Journal of Orthopaedic Surgery·Takashi TomaFuminori Kanaya
Oct 16, 2018·Orthopaedic Journal of Sports Medicine·Jeffrey JancuskaLeslie J Bisson
May 11, 2016·Molecular and Cellular Biochemistry·Finosh G ThankamDevendra K Agrawal
Oct 3, 2009·Clinical Orthopaedics and Related Research·Tadanao FunakoshiMyron Spector
Feb 6, 2017·Clinical Orthopaedics and Related Research·Jorge H AssunçãoArnaldo A Ferreira Neto
Jun 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·He LiangGiuseppe Tronci
Dec 7, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Du-Han KimChul-Hyun Cho
Jul 21, 2021·The American Journal of Sports Medicine·Jessica M EagerKara L Spiller

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