Multivariate analysis of prognostic factors in 106 patients with malignant glioma

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E SalminenS Huhtala

Abstract

The aim of this study was to evaluate the outcome and prognostic factors influencing survival in 106 patients with supratentorial malignant gliomas treated with radiotherapy. The study group included 84 patients treated by surgery and post-operative radiotherapy and 22 patients treated by postbiopsy irradiation. Radiotherapy was delivered to the tumour area with a 2 cm margin, the aimed curative dose was 60 Gy in 6-7 weeks. The 60-month overall survival (Kaplan-Meier) was 20%. Following a univariate analysis, younger age (P < 0.001), longer duration of symptoms (P = 0.009), good performance status after radiotherapy (P < 0.001), other than grade 4 histology (P < 0.001) and higher radiation dose (P < 0.001) were associated with better overall survival rates. Multivariate analysis found that age, symptom duration, histology, extent of symptoms and radiation dose were independent prognostic factors influencing survival. In conclusion, conventional radiotherapy of supratentorial malignant gliomas results in survival that is comparable to results from clinical experiments with different fractionation schedules and radiation with chemotherapy or radiosensitisers. To improve the results, new approaches are needed, especially for patie...Continue Reading

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Citations

Apr 28, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T VeningaR W van der Maazen
Sep 29, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A LiigantA E Kaasik
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E SalminenL Teppo
Aug 16, 2001·Journal of the National Cancer Institute·J S SmithR B Jenkins
Dec 27, 2007·Neurologia Medico-chirurgica·Masanori KurimotoShunro Endo
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Jul 26, 2012·British Journal of Neurosurgery·Sang-Deok KimEun-Hui Jeong
Jan 9, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaya MiyazakiShinya Tanaka
Apr 2, 2004·American Journal of Clinical Oncology·Branislav JeremicNebojsa Nikolic
Aug 10, 2012·Journal of Neuro-oncology·Denice D Tsao-WeiMarc C Chamberlain

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