Abstract
Determination of prognosis factors associated with survival, recurrence, progression, and development of metastasis in T1 and T2a transitional cell carcinoma (TCC) of the bladder is discussed. A study was conducted of a group of 210 patients with primary bladder TCC at classification T1 (n = 175) and T2aN0M0 (n = 35). A total of 177 variables were studied in each patient. The monoclonal antibodies used were the following: DO7 (p53) and MIB-1 (Ki-67). Prognosis was obtained using Kaplan-Meier methodology and Cox proportional hazards model. The average follow-up period was 6.7 years. Cancer-related survival rates at 5 and 10 years were 82.96% and 74.78%, respectively. The independent survival variables were the following: age and expression of p53. Recurrence free survival at 5 and 10 years stood at 51.80% and 42.71%, respectively. The independent recurrence variables were T2a classification, tumor multifocality, tumor size of greater than 3 cm, carcinoma in situ in random biopsy, and expression of Ki-67. Progression free survival rates at 5 and 10 years were 75.31% and 69.16%, respectively. The independent progression variables were age, T2a classification, and expression of p53. Metastasis free survival rates at 5 and 10 years ...Continue Reading
References
Dec 1, 1991·The Journal of Urology·P K LipponenE Pesonen
Aug 1, 1989·The Journal of Urology·M K ParmarD A Tolley
Jan 1, 1987·Urologia Internationalis·M TakashiY Ohno
Jul 1, 1983·The Journal of Urology·A S NarayanaD A Culp
Jan 1, 1995·British Journal of Cancer·J SerthU Jonas
Nov 10, 1994·The New England Journal of Medicine·D EsrigR J Cote
Feb 1, 1994·British Journal of Urology·J A WitjesF M Debruyn
Apr 1, 1994·British Journal of Urology·P F MuldersF M Debruyne
Dec 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A KuczykU Jonas
Mar 1, 1997·British Journal of Urology·M TsujiS Kagawa
Jun 20, 1998·British Journal of Urology·P AllardB Têtu
Jun 27, 1998·European Urology·Y FujiiH Oshima
Aug 28, 1998·The Journal of Urology·J P SteinR J Cote
Sep 29, 1998·The Journal of Urology·S Jahnson, M G Karlsson
Jan 14, 1999·Urology·A PychaM Marberger
Feb 18, 1999·The Journal of Urology·A R ZlottaC C Schulman
Oct 12, 1999·European Urology·T LiukkonenP Lipponen
Nov 26, 1999·Human Pathology·C PfisterY Fradet
Dec 22, 1999·The Journal of Urology·F Millán-RodríguezJ Vicente-Rodríguez
Citations
Sep 28, 2004·Pathology Oncology Research : POR·Zahra AmirghofranZahra Malek-Hosseini
Aug 27, 2002·Current Treatment Options in Oncology·Fabio Calabrò, Cora N Sternberg
Jun 21, 2005·European Urology·A OrsolaI Orsola
May 21, 2004·American Journal of Clinical Pathology·Hui Yin, Anthony S Y Leong
Apr 22, 2009·AJR. American Journal of Roentgenology·Haruo WatanabeNoriyuki Moriyama
Feb 2, 2013·Journal of Mid-life Health·Abbas RezaianzadehNarges Mohammadsalehi
Jul 15, 2015·Histopathology·I-Wei ChangChien-Feng Li
Nov 28, 2008·BJU International·Matthew R BraaschMichael A O'Donnell
Feb 1, 2008·Human Pathology·Ming YinRajiv Dhir
Jul 10, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Akinori SatohSo Nakamura
Jun 24, 2004·Cancer·Rajesh JaganathDavid L Rimm
Apr 1, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Sentai DingHiroyuki Nishiyama
Apr 21, 2006·European Urology·Andriy O YurakhAntonio Llombart-Bosch
Jun 18, 2011·Scandinavian Journal of Urology and Nephrology·Georg JanckeStaffan Jahnson
Apr 8, 2015·PloS One·Shenghua LiuQiang Ding
Sep 22, 2011·Urologia Internationalis·Mansur Dağgülliİrfan Orhan
Jul 5, 2006·Urologic Oncology·Fadi N JoudiUNKNOWN National BCG-Interferon Phase 2 Investigator Group
Jun 7, 2012·Korean journal of urology·Ji Yong LeeSe Joong Kim
Jul 23, 2020·Journal of Cellular Physiology·Hanieh AzariMohammad Shekari
Nov 24, 2012·Revista do Colégio Brasileiro de Cirurgiões·Daniel Cury OgataLetícia Elizabeth Augustin Czeczko
Apr 26, 2003·Virchows Archiv : an International Journal of Pathology·Burkhard HelpapMichael J Droller
Sep 10, 2003·Journal of Chemotherapy·M R RaspolliniG L Taddei
Jan 1, 2007·Biomarker Insights·Andrea Brunner, Alexandar Tzankov
Apr 16, 2016·Medicine·Yihuan LuoGang Chen
Dec 17, 2020·The Veterinary Journal·M ShinadaT Nakagawa