Multivariate expression analysis of the gene network underlying sexual development in turtle embryos with temperature-dependent and genotypic sex determination

Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
Nicole Valenzuela

Abstract

Sexual development has long been the target of study and despite great advances in our understanding of the composition and regulation of the gene network underlying gonadogenesis, our knowledge remains incomplete. Of particular interest is the relative role that the environment and the genome play in directing gonadal formation, especially the effect of environmental temperature in directing this process in vertebrates. Comparative analyses in closely related taxa with contrasting sex-determining mechanisms should help fill this gap. Here I present a multivariate study of the regulation of the gene network underlying sexual development in turtles with temperature-dependent (TSD; Chrysemys picta) and genotypic sex determination (GSD; Apalone mutica). I combine novel data on SOX9 and DMRT1 from these species with contrasting sex-determining mechanisms for the first time with previously reported data on DAX1, SF-1 (NR5A1), WT1, and aromatase (CYP19A1) from these same taxa. Comparative expression analyses of SOX9 and DMRT1 from these and other species indicate additional elements whose expression has diverged among TSD taxa, further supporting the notion that significant evolutionary changes have accrued in the regulation of the T...Continue Reading

Citations

Jul 2, 2014·PLoS Biology·Doris BachtrogUNKNOWN Tree of Sex Consortium
Oct 1, 2011·The Quarterly Review of Biology·Tobias Uller, Heikki Helanterä
Dec 12, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Seba Jamal Shbailat, Ehab Abouheif
Mar 6, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Julien BéhagueMathieu Molet
Oct 31, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicole ValenzuelaRobert Literman
Oct 3, 2018·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Srihari RadhakrishnanNicole Valenzuela
Jun 8, 2011·Evolution; International Journal of Organic Evolution·Nicole Valenzuela, Dean C Adams

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