PMID: 7535828Apr 1, 1995Paper

Multivariate models for predicting progression to AIDS and survival in human immunodeficiency virus-infected persons

The Journal of Infectious Diseases
S P BlattW W Ward

Abstract

Nine hundred thirty persons enrolled in the US Air Force Human Immunodeficiency Virus (HIV) Natural History Study were evaluated with a standard battery of 30 potential surrogate markers of disease progression. A risk score for predicting progression to AIDS was then calculated for each patient in the cohort by using the four highest-ranking variables from multivariate analysis: percentage of CD4 CD29 cells, anergy status, age, and hemoglobin. For predicting survival, beta 2-microglobulin replaced age in the Cox model. Stratification according to the risk score demonstrated that rates of progression to AIDS and survival were significantly different between risk groups (P < .0001). The novel combination of these markers results in extremely accurate risk scores, which may serve as the basis for the development of true surrogate markers of disease progression.

Citations

Nov 14, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M HeinkeleinC Jassoy
Jun 1, 1997·Mechanisms of Ageing and Development·W H AdlerJ E Nagel
Feb 25, 2003·The Journal of the Acoustical Society of America·Torsten Dau
Aug 22, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Alan L LinChih-Ko Yeh
Aug 27, 2003·Journal of Dental Research·A L LinC-K Yeh
May 19, 2006·AIDS Research and Human Retroviruses·Dora LarussaUNKNOWN Italian Registry Investigative Neuro AIDS (IRINA)
Apr 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S PueyoR Salamon

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