PMID: 11899067Mar 20, 2002Paper

Multivariate pharmaceutical profiling for drug discovery

Current Topics in Medicinal Chemistry
Edward H Kerns, Li Di

Abstract

The field of pharmaceutical profiling in drug discovery is described. The pharmaceutical properties of drug candidates determine how much of the drug safely reaches the therapeutic target. Drug candidates often fail in discovery and development due to inadequate properties, resulting in lost opportunities and resources for developing new drugs. Pharmaceutical profiling assays have been developed and implemented to measure the properties of large numbers of drug candidates starting at the earliest stages of discovery. This information is used for informed decisions in drug candidate selection and synthetic optimization. A holistic process of parallel activity and property optimization has emerged in drug discovery. The assays, strategies, and data management associated with pharmaceutical profiling are discussed.

Citations

Mar 26, 2003·Drug Discovery Today·Edward H Kerns, Li Di
Jun 27, 2003·Current Opinion in Chemical Biology·Li Di, Edward H Kerns
Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Alex Avdeef
Nov 22, 2005·Expert Opinion on Drug Delivery·Isabel Gomez-Orellana
Jul 22, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alex AvdeefOksana Tsinman
Dec 1, 2018·Current Topics in Medicinal Chemistry·Hai Pham-TheGerardo M Casañola-Martin
Mar 1, 2009·Expert Review of Clinical Pharmacology·Nikoletta Fotaki
Oct 18, 2011·Current Opinion in Infectious Diseases·Robert T JacobsMartine Keenan
Apr 2, 2003·European Journal of Medicinal Chemistry·Li DiGuy T Carter

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