Multivariate survival analysis of clinicopathologic features in surgical stage I endometrioid carcinoma including analysis of HER-2/neu expression

American Journal of Obstetrics and Gynecology
T NazeerR A Ambros

Abstract

We previously described vascular invasion-associated changes, defined as the presence of vascular invasion or perivascular lymphocytic infiltrates, as key prognostic indicators in stage I endometrioid carcinoma. The current study was undertaken to examine the prognostic value of HER-2/neu expression in relation to other factors, including vascular invasion-associated changes, in surgical stage I endometrioid carcinoma. Seventy-one patients with surgical stage I endometrioid carcinoma treated by hysterectomy and followed up were randomly chosen for retrospective analysis of prognostic indicators including standard clincopathologic features, deoxyribonucleic acid ploidy, and HER-2/neu expression. The latter was examined by an objective computerized quantitative immunohistochemical system. By univariate analysis many factors were found to correlate with outcome, including age, tumor grade, depth of invasion, ploidy, HER-2/neu expression, and vascular invasion-associated changes. By multivariate analysis only vascular invasion-associated changes, aneuploidy, and HER-2/neu overexpression were found to independently correlate with survival. Stratification of patients on the basis of these three features revealed survival rates of 100...Continue Reading

References

Nov 1, 1992·Gynecologic Oncology·D J HetzelK C Podratz
Sep 1, 1989·Gynecologic Oncology·L C BrittonK C Podratz

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Citations

Mar 15, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Erika NordbergBengt Glimelius
Feb 14, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Helga B Salvesen, Lars A Akslen
May 10, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anita SteinbakkJan P Baak
Jul 30, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anjila KoulR Willén
Mar 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J KurokiY Udagawa
Jul 2, 2005·Cancer Biotherapy & Radiopharmaceuticals·Ann-Charlott SteffenJörgen Carlsson
Mar 1, 2014·Archives of Pathology & Laboratory Medicine·Natalia BuzaAlessandro D Santin
Jul 27, 1999·Gynecologic Oncology·H AshihA Berchuck
Mar 10, 2001·Cancer Treatment Reviews·B A Jereczek-Fossa
Sep 15, 2005·Gynecologic Oncology·Chad A LivasyRuth A Lininger
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carl MorrisonJeffrey M Fowler
Dec 14, 2006·Human Molecular Genetics·Kristjana EinarsdóttirSara Wedrén

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