Multivariate white matter alterations are associated with epilepsy duration.

The European Journal of Neuroscience
Thomas W OwenPeter N Taylor

Abstract

Previous studies investigating associations between white matter alterations and duration of temporal lobe epilepsy (TLE) have shown differing results, and were typically limited to univariate analyses of tracts in isolation. In this study, we apply a multivariate measure (the Mahalanobis distance), which captures the distinct ways white matter may differ in individual patients, and relate this to epilepsy duration. Diffusion MRI, from a cohort of 94 subjects (28 healthy controls, 33 left-TLE and 33 right-TLE), was used to assess the association between tract fractional anisotropy (FA) and epilepsy duration. Using ten white matter tracts, we analysed associations using the traditional univariate analysis (z-scores) and a complementary multivariate approach (Mahalanobis distance), incorporating multiple white matter tracts into a single unified analysis. For patients with right-TLE, FA was not significantly associated with epilepsy duration for any tract studied in isolation. For patients with left-TLE, the FA of two limbic tracts (ipsilateral fornix, contralateral cingulum gyrus) were significantly negatively associated with epilepsy duration (Bonferonni corrected p < .05). Using a multivariate approach we found significant ips...Continue Reading

References

Apr 24, 2002·NeuroImage·Claudia A M Wheeler-KingshottGareth J Barker
Nov 5, 2002·Magnetic Resonance Imaging·Konstantinos ArfanakisMary E Meyerand
Feb 26, 2003·Annals of Neurology·Rebecca S N LiuJohn S Duncan
Jul 29, 2006·NeuroImage·Leonardo BonilhaLi Min Li
Apr 26, 2007·Journal of Magnetic Resonance Imaging : JMRI·Philip A CookDaniel C Alexander
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Apr 26, 2008·Epilepsy Research·Rajkumar Munian GovindanHarry T Chugani
Oct 3, 2008·Epilepsy Research·Jack J LinSteven C Cramer
Nov 4, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·L ConchaD W Gross
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander Leemans, Derek K Jones
Jun 11, 2009·AJNR. American Journal of Neuroradiology·M E AhmadiE Halgren
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luis ConchaDonald W Gross
Mar 9, 2010·NeuroImage·Michael WahlPratik Mukherjee
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Jan 28, 2012·AJNR. American Journal of Neuroradiology·E WidjajaM L Smith
Sep 8, 2012·Epilepsy Research and Treatment·Jose F Téllez-Zenteno, Lizbeth Hernández-Ronquillo
Mar 15, 2013·Frontiers in Neuroscience·José M SoaresNuno Sousa
Jul 16, 2013·Neuroscience and Biobehavioral Reviews·Marco CataniMichel Thiebaut de Schotten
Jan 7, 2014·NeuroImage. Clinical·Gavin P WinstonJohn S Duncan
May 13, 2014·NeuroImage·Pierre BessonSophie Dupont
Oct 21, 2015·NeuroImage·Jesper L R Andersson, Stamatios N Sotiropoulos
Jan 30, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sjoerd B VosMartijn Froeling
Aug 2, 2016·Australian & New Zealand Journal of Statistics·Paul H Garthwaite, Inge Koch
Dec 16, 2016·Nature Communications·Simon R CoxIan J Deary
Dec 30, 2016·Brain : a Journal of Neurology·Simon S KellerLeonardo Bonilha
Jan 19, 2018·Acta Neurologica Scandinavica·K M ParkS E Kim
Jan 25, 2018·Brain : a Journal of Neurology·Christopher D WhelanSanjay M Sisodiya
Jun 8, 2018·NeuroImage. Clinical·Peter N TaylorJohn S Duncan

❮ Previous
Next ❯

Software Mentioned

_ correct
R
Studio
MASS package
_ bvecs
DSI
fdt
FSL
eddy

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.