Multivisceral resection does not affect morbidity and survival after cytoreductive surgery and chemoperfusion for carcinomatosis from colorectal cancer

Annals of Surgical Oncology
Jan FrankoD Bartlett

Abstract

Carcinomatosis of colorectal origin is increasingly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS-HIPEC). This procedure commonly involves multivisceral resection (MVR) with potentially high morbidity. We analyzed the effect of MVR on the outcome after CS-HIPEC. All patients with colorectal carcinomatosis operated between June 2001 and June 2007 were included. MVR was defined as resection of two or more organs (n = 35). Patients without any or with a single visceral resection formed a control group (n = 30). Sixty-five patients underwent 72 procedures. MVR was not strongly associated with the mortality, morbidity, reoperation, or readmission. Morbidity, but not mortality, was more common in patients requiring bowel anastomosis (36 of 51 vs. 7 of 21, P = .003). Median survival from the diagnosis of carcinomatosis was not significantly different between the MVR and controls (32.8 months vs. 20.0 months, P = .787). Similarly, the median survival from the time of cytoreduction was not significantly different (20.2 vs. 14.3 months; P = .436). Independent predictors of survival in the Cox regression model were presence of residual disease >5 mm (hazard ratio = 4.5, P = .048), evidence of carcinoma...Continue Reading

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Citations

Mar 1, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Parissa TabrizianDaniel M Labow
Jun 25, 2013·Journal of Gastroenterology·Hirotoshi KobayashiUNKNOWN Study Group for Peritoneal Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum
Dec 16, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Wenceslao Vásquez JiménezSantiago González Moreno
Sep 13, 2008·Annals of Surgical Oncology·George J Chang, Laura A Lambert
Mar 5, 2013·Annals of Surgical Oncology·Patrick L WagnerHaroon A Choudry
Mar 1, 2012·Cancer Investigation·Björn L D M BrücherAviram Nissan
Apr 12, 2016·Indian Journal of Surgical Oncology·Aditi Bhatt, Diane Goéré
Apr 12, 2016·Indian Journal of Surgical Oncology·Sanket S MehtaOlivier Glehen
Nov 3, 2012·Hematology/oncology Clinics of North America·Suven ShankarArmando Sardi
Jun 13, 2012·Journal of Surgical Oncology·Terence C ChuaDavid L Morris
Oct 27, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P Horvath, A Königsrainer
Jun 27, 2009·The Cancer Journal·Philip Bao, David Bartlett
Jul 20, 2012·Diseases of the Colon and Rectum·George J ChangUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons

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