Multivitamin-mineral use is associated with reduced risk of cardiovascular disease mortality among women in the United States

The Journal of Nutrition
Regan Lucas BaileyDavid M Murray

Abstract

Multivitamin-mineral (MVM) products are the most commonly used supplements in the United States, followed by multivitamin (MV) products. Two randomized clinical trials (RCTs) did not show an effect of MVMs or MVs on cardiovascular disease (CVD) mortality; however, no clinical trial data are available for women with MVM supplement use and CVD mortality. The objective of this research was to examine the association between MVM and MV use and CVD-specific mortality among US adults without CVD. A nationally representative sample of adults from the restricted data NHANES III (1988-1994; n = 8678; age ≥40 y) were matched with mortality data reported by the National Death Index through 2011 to examine associations between MVM and MV use and CVD mortality by using Cox proportional hazards models, adjusting for multiple potential confounders. We observed no significant association between CVD mortality and users of MVMs or MVs compared with nonusers; however, when users were classified by the reported length of time products were used, a significant association was found with MVM use of >3 y compared with nonusers (HR: 0.65; 95% CI: 0.49, 0.85). This finding was largely driven by the significant association among women (HR: 0.56; 95% CI...Continue Reading

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Citations

Aug 25, 2016·Nutrition·Hans K Biesalski, Jana Tinz
Jun 14, 2017·The British Journal of Nutrition·Birta ÓlafsdóttirKristjana Einarsdóttir
Apr 29, 2016·The Journal of Nutrition·Susanne RautiainenHoward D Sesso
Jul 12, 2018·Circulation. Cardiovascular Quality and Outcomes·Joonseok KimErin D Michos
Sep 22, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Stéphane Walrand
Oct 31, 2018·The Proceedings of the Nutrition Society·Marleen A H Lentjes
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Mar 2, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Paul F Jacques, Gail Rogers
May 24, 2017·Journal of Agricultural and Food Chemistry·Weeraya KarnpanitVijay Jayasena

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