Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects.

JAMA : the Journal of the American Medical Association
A MilunskyW Willett

Abstract

We examined the relation of multivitamin intake in general, and folic acid in particular, to the risk of neural tube defects in a cohort of 23,491 women undergoing maternal serum alpha-fetoprotein screening or amniocentesis around 16 weeks of gestation. Complete questionnaires and subsequent pregnancy outcome information was obtained in 22,776 pregnancies, 49 of which ended in a neural tube defect. The prevalence of neural tube defect was 3.5 per 1000 among women who never used multivitamins before or after conception or who used multivitamins before conception only. The prevalence of neural tube defects for women who used folic acid-containing multivitamins during the first 6 weeks of pregnancy was substantially lower--0.9 per 1000 (prevalence ratio, 0.27; 95% confidence interval, 0.12 to 0.59 compared with never users). For women who used multivitamins without folic acid during the first 6 weeks of pregnancy and women who used multivitamins containing folic acid beginning after 7 or more weeks of pregnancy, the prevalences were similar to that of the nonusers and the prevalence ratios were close to 1.0.

Citations

Dec 19, 2012·Journal of Pediatric Neurosciences·Vijayendra KumarAjay Narayan Gangopadhyay
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·B C BlountB N Ames
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·T H RosenquistJ Selhub
Apr 8, 2014·Journal of Neurosurgery. Pediatrics·Varun R KshettryRobert J Weil
Dec 17, 2014·Obstetrical & Gynecological Survey·Norman B DuerbeckJillinda M Duerbeck
Nov 28, 2012·Women's Health·Anita L Nelson
May 1, 1992·American Journal of Public Health·W C Willett
Jan 1, 1992·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·N T Glanville, H W Cook
Jul 21, 1990·BMJ : British Medical Journal·S Truswell
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J T MacGregorB N Ames
May 1, 1995·American Journal of Public Health·P S RomanoR D Pi
Feb 1, 1995·American Journal of Public Health·M M Werler, A A Mitchell
Dec 1, 1993·Environmental Health Perspectives·M G Costantini
Mar 1, 1994·American Journal of Public Health·S A Beresford
May 1, 1994·American Journal of Public Health·M Susser
Sep 1, 1995·Environmental Health Perspectives·J A Harris, G M Shaw
May 1, 1996·American Journal of Public Health·M Susser, E Susser
Nov 30, 1999·American Journal of Public Health·M M WerlerA A Mitchell
Jun 9, 2005·Neurotoxicology and Teratology·Eric R DetraitMarcy C Speer
Aug 23, 2006·Nature Reviews. Neuroscience·Henk J BlomRichard H Finnell
Oct 5, 2006·American Journal of Public Health·Tanya G K BentleyKaren M Kuntz
Oct 28, 2008·American Journal of Epidemiology·James L Mills, Tonia C Carter
Oct 28, 2008·American Journal of Epidemiology·Bridget S MosleyUNKNOWN National Birth Defects Prevention Study
Apr 2, 2010·International Journal of Epidemiology·Hannah BlencoweJoy Lawn
Jul 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah G ObicanAnthony R Scialli
Oct 13, 2011·JAMA : the Journal of the American Medical Association·Christine RothEzra Susser
Oct 3, 2012·Journal of Pregnancy·Noelle Ma, Daniel B Hardy
Feb 14, 2013·JAMA : the Journal of the American Medical Association·Pål SurénCamilla Stoltenberg
Sep 21, 2013·International Journal of Environmental Research and Public Health·Apolline ImbardHenk J Blom
Jan 20, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Edward SyskaJohannes Schubert
Apr 12, 2002·American Journal of Epidemiology·Lynn L MooreAubrey Milunsky
Feb 7, 1998·Reproductive Toxicology·R K MillerU W Wiegand
Oct 1, 1990·Controlled Clinical Trials·N Wald
Jul 26, 2002·Journal of Occupational and Environmental Medicine·Jean BrenderRussell Larsen
Dec 16, 1998·Journal of the American College of Nutrition·M L NeuhouserE R Monsen
Nov 4, 2008·Journal of the American College of Nutrition·Márta BognárMiklós Garami
Aug 1, 1993·Journal of the American College of Nutrition·C E Butterworth
Apr 1, 1994·Journal of the American College of Nutrition·R D Reynolds
Apr 1, 1996·Journal of the American College of Nutrition·W F RayburnM E Garrett
Mar 15, 2001·Epidemiology·L A TurnerV M Prabhakaran
Feb 24, 2009·Epidemiology·Suzan L CarmichaelGary M Shaw
Feb 28, 2003·Epidemiology·Lynn L MooreAubrey Milunsky

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