Multivortex micromixing.

Proceedings of the National Academy of Sciences of the United States of America
Arjun P Sudarsan, Victor M Ugaz

Abstract

The ability to mix liquids in microchannel networks is fundamentally important in the design of nearly every miniaturized chemical and biochemical analysis system. Here, we show that enhanced micromixing can be achieved in topologically simple and easily fabricated planar 2D microchannels by simply introducing curvature and changes in width in a prescribed manner. This goal is accomplished by harnessing a synergistic combination of (i) Dean vortices that arise in the vertical plane of curved channels as a consequence of an interplay between inertial, centrifugal, and viscous effects, and (ii) expansion vortices that arise in the horizontal plane due to an abrupt increase in a conduit's cross-sectional area. We characterize these effects by using confocal microscopy of aqueous fluorescent dye streams and by observing binding interactions between an intercalating dye and double-stranded DNA. These mixing approaches are versatile and scalable and can be straightforwardly integrated as generic components in a variety of lab-on-a-chip systems.

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Citations

Apr 27, 2010·Analytical and Bioanalytical Chemistry·Daniel R GossettDino Di Carlo
Jun 28, 2012·Biomedical Microdevices·Yongbo DengYihui Wu
Aug 3, 2010·Nanoscale Research Letters·Liqiu Wang, Jing Fan
May 9, 2013·Nature Communications·Hamed AminiDino Di Carlo
Mar 29, 2008·Lab on a Chip·Chi-Shuo ChenMichelle Khine
Oct 14, 2009·Lab on a Chip·Dino Di Carlo
Jun 22, 2010·Lab on a Chip·Jun WangChang Lu
Apr 12, 2011·Lab on a Chip·Matthias GeisslerTeodor Veres
Jul 22, 2011·Lab on a Chip·Debapriya ChakrabortySuman Chakraborty
Jul 27, 2012·Lab on a Chip·Serdar OzturkVictor M Ugaz
Jul 5, 2013·Lab on a Chip·Maïwenn Kersaudy-Kerhoas, Elodie Sollier
Jul 13, 2011·International Journal of Molecular Sciences·Jyh Jian ChenShian Ruei Shie
Jan 27, 2011·Biomicrofluidics·Sung Hwan ChoYu-Hwa Lo
May 9, 2012·The Review of Scientific Instruments·Subrata BatabyalSamir Kumar Pal
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dino Di CarloMehmet Toner
Apr 17, 2014·Biomicrofluidics·Jeffrey M BurkeIan M White
Apr 5, 2011·Annual Review of Analytical Chemistry·Jason S Kuo, Daniel T Chiu
Jul 1, 2014·Nanomedicine·Daniel JaqueJosé García Solé
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Aug 29, 2012·Angewandte Chemie·Jen-Huang HuangVictor M Ugaz
Jul 17, 2010·Biomedical Microdevices·Myung Gwon LeeJe-Kyun Park
Dec 21, 2006·Lab on a Chip·Curtis D ChinSamuel K Sia

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